Reactome | SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)

SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)

Stable Identifier

R-HSA-2179407

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Gastrin-CREB signalling pathway via PKC and MAPK (Homo sapiens)
        
        EGFR Transactivation by Gastrin (Homo sapiens)
        
        SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Homo sapiens)

General

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SVG | | PPTX | SBGN

SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)

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SOS1 is the guanine nucleotide exchange factor (GEF) for RAS. SOS1 activates RAS nucleotide exchange from the inactive form (bound to GDP) to an active form (bound to GTP) (Chardin et al. 1993).

Literature References

PubMed ID	Title	Journal	Year
8493579	Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2 Gale, NW, Camonis, JH, Chardin, P, Schlessinger, J, Wigler, MH, Bar-Sagi, D, Van Aelst, L	Science	1993