Reactome | UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1

UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1

Stable Identifier

R-HSA-2179293

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

5/5

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UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1

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Ubiquitin C-terminal hydrolase UCHL5 (UCH37) strongly binds to SMAD7 and is thereby recruited to TGF-beta receptor complex (Wicks et al. 2005). Another ubiquitin peptidase, USP15, has recently been found to associate with ubiquitinated TGFBR1 through SMAD7 (Eichhorn et al. 2012). The role of UCHL5 was inferred from experiments using recombinant mouse Uchl5 and Smad7 with recombinant human TGF-beta receptors. The role of USP15 was established by experiments with human proteins.

Literature References

PubMed ID	Title	Journal	Year
22344298	USP15 stabilizes TGF-? receptor I and promotes oncogenesis through the activation of TGF-? signaling in glioblastoma Aura, C, Martínez-Sáez, E, Barba, I, Baselga, J, Eichhorn, PJ, Prat, A, Peg, V, García-Dorado, D, Bernards, R, Cuartas, I, Jimenez, J, Seoane, J, Gili, M, Dirac, A, Gonzàlez-Juncà, A, Sahuquillo, J, Rodón, L	Nat Med	2012
16027725	The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling Haros, K, Maillard, M, Song, L, Dijke, PT, Cohen, RE, Chantry, A, Wicks, SJ	Oncogene	2005