UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1

Stable Identifier
R-HSA-2179293
Type
Reaction
Species
Homo sapiens
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Ubiquitin C-terminal hydrolase UCHL5 (UCH37) strongly binds to SMAD7 and is thereby recruited to TGF-beta receptor complex (Wicks et al. 2005). Another ubiquitin peptidase, USP15, has recently been found to associate with ubiquitinated TGFBR1 through SMAD7 (Eichhorn et al. 2012). The role of UCHL5 was inferred from experiments using recombinant mouse Uchl5 and Smad7 with recombinant human TGF-beta receptors. The role of USP15 was established by experiments with human proteins.

Literature References
PubMed ID Title Journal Year
22344298 USP15 stabilizes TGF-? receptor I and promotes oncogenesis through the activation of TGF-? signaling in glioblastoma

Aura, C, Martínez-Sáez, E, Barba, I, Baselga, J, Eichhorn, PJ, Prat, A, Peg, V, García-Dorado, D, Bernards, R, Cuartas, I, Jimenez, J, Seoane, J, Gili, M, Dirac, A, Gonzàlez-Juncà, A, Sahuquillo, J, Rodón, L

Nat Med 2012
16027725 The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling

Haros, K, Maillard, M, Song, L, Dijke, PT, Cohen, RE, Chantry, A, Wicks, SJ

Oncogene 2005
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