FMO1:FAD N-oxidises TAM

Stable Identifier
R-HSA-217255
Type
Reaction [transition]
Species
Homo sapiens
Compartment
smooth endoplasmic reticulum
Synonyms
FMO1 N-oxidizes the anti-cancer drug tamoxifen
ReviewStatus
5/5
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FMO1:FAD N-oxidises TAM
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Tamoxifen (TAM) is an antiestrogen and currently used extensively for breast cancer therapy. FMOs, especially FMO1 can N-oxidze TAM to tamoxifen N-oxide (TNO). TNO can be reduced back to TAM by the P450 system. TNO appears to be just as potent as TAM but with fewer side-effects so this metabolic cycling could play a part in the use of TNO in the treatment of breast cancer.
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Catalyst Activity

N,N-dimethylaniline monooxygenase activity of FMO1:FAD [endoplasmic reticulum membrane]

Physical Entity
FMO1:FAD [endoplasmic reticulum membrane] (Homo sapiens)
Activity
N,N-dimethylaniline monooxygenase activity (GO:0004499)
Orthologous Events
FMO1:FAD N-oxidises TAM (Bos taurus)
FMO1:FAD N-oxidises TAM (Caenorhabditis elegans)
FMO1:FAD N-oxidises TAM (Canis familiaris)
FMO1:FAD N-oxidises TAM (Danio rerio)
FMO1:FAD N-oxidises TAM (Dictyostelium discoideum)
FMO1:FAD N-oxidises TAM (Mus musculus)
FMO1:FAD N-oxidises TAM (Rattus norvegicus)
FMO1:FAD N-oxidises TAM (Sus scrofa)
FMO1:FAD N-oxidises TAM (Xenopus tropicalis)
Authored
Jassal, B  (2008-05-19)
Reviewed
D'Eustachio, P  (2008-05-28)
D'Eustachio, P  (2023-08-18)
Created
Jassal, B  (2008-03-26)
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