Truncated Alpha-1-Microglobulin binds heme

Stable Identifier
R-HSA-2168881
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Truncated Alpha-1-Microglobulin binds heme
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Truncated Alpha-1-Microglobulin binds heme b and then degrades heme b by an unknown mechanism (Allhorn et al. 2002). The crystal structure of the untruncated Alpha1-Microglobulin:heme complex indicates that each Alpha1-Microglobulin molecule binds 2 heme molecules and the Alpha1-Microglobulin molecules trimerize (Siebel et al. 2012).
Literature References
PubMed ID Title Journal Year
22492620 Insertion of heme b into the structure of the Cys34-carbamidomethylated human lipocalin ?(1)-microglobulin: formation of a [(heme)(2) (?(1)-Microglobulin)](3) complex

Siebel, JF, Åkerström, B, Kosinsky, RL, Knipp, M

Chembiochem 2012
11877257 Processing of the lipocalin alpha(1)-microglobulin by hemoglobin induces heme-binding and heme-degradation properties

Allhorn, M, Berggård, T, Nordberg, J, Olsson, ML, Akerström, B

Blood 2002
Participants
Input
Output
Participates
as an event of
Orthologous Events
Truncated Alpha-1-Microglobulin binds heme (Canis familiaris)
Truncated Alpha-1-Microglobulin binds heme (Danio rerio)
Truncated Alpha-1-Microglobulin binds heme (Gallus gallus)
Truncated Alpha-1-Microglobulin binds heme (Mus musculus)
Truncated Alpha-1-Microglobulin binds heme (Rattus norvegicus)
Truncated Alpha-1-Microglobulin binds heme (Sus scrofa)
Truncated Alpha-1-Microglobulin binds heme (Xenopus tropicalis)
Authored
May, B  (2012-03-21)
Reviewed
Tolosano, E  (2013-02-13)
Moestrup, SK  (2013-02-18)
Fiorito, V  (2013-02-13)
Created
May, B  (2012-03-25)
Cite Us!