Truncated Alpha-1-Microglobulin binds heme

Stable Identifier
R-HSA-2168881
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Truncated Alpha-1-Microglobulin binds heme b and then degrades heme b by an unknown mechanism (Allhorn et al. 2002). The crystal structure of the untruncated Alpha1-Microglobulin:heme complex indicates that each Alpha1-Microglobulin molecule binds 2 heme molecules and the Alpha1-Microglobulin molecules trimerize (Siebel et al. 2012).

Literature References
PubMed ID Title Journal Year
11877257 Processing of the lipocalin alpha(1)-microglobulin by hemoglobin induces heme-binding and heme-degradation properties

Allhorn, M, Berggård, T, Nordberg, J, Olsson, ML, Akerström, B

Blood 2002
22492620 Insertion of heme b into the structure of the Cys34-carbamidomethylated human lipocalin ?(1)-microglobulin: formation of a [(heme)(2) (?(1)-Microglobulin)](3) complex

Siebel, JF, Kosinsky, RL, Åkerström, B, Knipp, M

Chembiochem 2012
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created
Cite Us!