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SMAD7:SMURF2 [nucleoplasm]
Stable Identifier
R-HSA-2167870
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling activates SMADs (Homo sapiens)
Downregulation of TGF-beta receptor signaling (Homo sapiens)
SMAD7 binds to SMURF2 (Homo sapiens)
SMAD7:SMURF2 [nucleoplasm] (Homo sapiens)
SMAD7:SMURF2 complex translocates to the cytosol (Homo sapiens)
SMAD7:SMURF2 [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
11163210
Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation
Thomsen, GH
,
Wrana, JL
,
Bonni, S
,
Causing, CG
,
Rasmussen, RK
,
Zhu, H
,
Kavsak, P
Mol Cell
2000
Participants
components
SMAD7 [nucleoplasm]
(Homo sapiens)
SMURF2 [nucleoplasm]
(Homo sapiens)
Participates
as an input of
SMAD7:SMURF2 complex translocates to the cytosol (Homo sapiens)
as an output of
SMAD7 binds to SMURF2 (Homo sapiens)
Inferred To
SMAD7:SMURF2 [nucleoplasm]
(Bos taurus)
SMAD7:SMURF2 [nucleoplasm]
(Canis familiaris)
SMAD7:SMURF2 [nucleoplasm]
(Danio rerio)
SMAD7:SMURF2 [nucleoplasm]
(Drosophila melanogaster)
SMAD7:SMURF2 [nucleoplasm]
(Gallus gallus)
SMAD7:SMURF2 [nucleoplasm]
(Mus musculus)
SMAD7:SMURF2 [nucleoplasm]
(Rattus norvegicus)
SMAD7:SMURF2 [nucleoplasm]
(Sus scrofa)
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