Reactome | SMAD7 binds to SMURF2

SMAD7 binds to SMURF2

Stable Identifier

R-HSA-178208

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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SMURF2, an E3 ubiquitin protein ligase, binds to SMAD7 in the nucleus. WW2 and WW3 domains of SMURF2 are both required for binding PY motif (PPXY sequence) of SMAD7. Endogenous human SMAD7 and SMURF2 were shown to form a complex in human U4A/Jak1 cells, derived from a sarcoma cell line 2fTGH. The interaction was studied in more detail by expressing tagged recombinant human SMURF2 and mouse Smad7 in human embryonic kidney cell line HEK293 (Kavsak et al. 2000, Ogunjimi et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
16061177	Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain Ogunjimi, AA, Briant, DJ, Pece-Barbara, N, Le Roy, C, Di Guglielmo, GM, Kavsak, P, Rasmussen, RK, Seet, BT, Sicheri, F, Wrana, JL	Mol Cell	2005
11163210	Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation Kavsak, P, Rasmussen, RK, Causing, CG, Bonni, S, Zhu, H, Thomsen, GH, Wrana, JL	Mol Cell	2000