Reactome | COQ3 methylates DHDB

COQ3 methylates DHDB

Stable Identifier

R-HSA-2162193

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

DHDB is methylated to MHDB by COQ3

ReviewStatus

5/5

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Mitochondrial O-methyltransferase COQ3 converts 3,4-dihydroxy-5-decaprenylbenzoic acid (DHDB) to 3-methoxy-4-hydroxy-5-decaprenylbenzoic acid (MHDB) (Jonassen & Clarke 2000). COQ3 is a membrane-associated protein (Zhu et al., 2015). COQ3 is phosphorylated by COQ8B at multiple sites (Nicoll et al., 2024).

Literature References

PubMed ID	Title	Journal	Year
38425362	In vitro construction of the COQ metabolon unveils the molecular determinants of coenzyme Q biosynthesis Gottinger, A, Mascotti, ML, Alvigini, L, Mattevi, A, Nicoll, CR, Cecchini, D, Corana, F, Mannucci, B	Nat Catal	2024
26251450	Structural and biochemical studies reveal UbiG/Coq3 as a class of novel membrane-binding proteins Zhang, X, Zhu, Y, Niu, L, Wu, B, Wang, J, Li, X, Fan, X, Teng, M	Biochem J	2015
10777520	Isolation and functional expression of human COQ3, a gene encoding a methyltransferase required for ubiquinone biosynthesis Jonassen, T, Clarke, CF	J Biol Chem	2000