MDMQ10H2 is methylated to DMQ10H2 by COQ5

Stable Identifier
R-HSA-2162188
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
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MDMQ10H2 is methylated to DMQ10H2 by COQ5
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2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial (COQ5) catalyses the C-methyltransferase conversion of 2-methoxy-6-decaprenyl-1,4-benzoquinol (MDMQ10H2) to 6-methoxy-3-methyl-2-decaprenyl-1,4-benzoquinol (DMQ10H2). This reaction is inferred from the equivalent reaction in yeast (Barkovich et al. 1997).

Literature References
PubMed ID Title Journal Year
9083049 Characterization of the COQ5 gene from Saccharomyces cerevisiae. Evidence for a C-methyltransferase in ubiquinone biosynthesis

Tzagoloff, A, Shepherd, JA, Shtanko, A, Barkovich, RJ, Lee, PT, Myles, DC, Clarke, CF

J Biol Chem 1997
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Catalyst Activity

2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity of COQ5 [mitochondrial matrix]

Physical Entity
COQ5 [mitochondrial matrix] (Homo sapiens)
Activity
2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity (GO:0043430)
Inferred From
MDMQ6H2 is methylated to DMQ6H2 by Coq5 (Saccharomyces cerevisiae)
Cross References
Rhea
Authored
Williams, MG  (2012-03-19)
Reviewed
Kawamukai, M  (2013-02-05)
Created
Williams, MG  (2012-03-15)
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