MDMQ10H2 is methylated to DMQ10H2 by COQ5

Stable Identifier
R-HSA-2162188
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial (COQ5) catalyses the C-methyltransferase conversion of 2-methoxy-6-decaprenyl-1,4-benzoquinol (MDMQ10H2) to 6-methoxy-3-methyl-2-decaprenyl-1,4-benzoquinol (DMQ10H2). This reaction is inferred from the equivalent reaction in yeast (Barkovich et al. 1997).

Literature References
PubMed ID Title Journal Year
9083049 Characterization of the COQ5 gene from Saccharomyces cerevisiae. Evidence for a C-methyltransferase in ubiquinone biosynthesis

Barkovich, RJ, Shtanko, A, Shepherd, JA, Lee, PT, Myles, DC, Tzagoloff, A, Clarke, CF

J Biol Chem 1997
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity of COQ5 [mitochondrial matrix]
Physical Entity
Activity
Inferred From
Cross References
Rhea
Authored
Reviewed
Created