MDMQ10H2 is methylated to DMQ10H2 by COQ5

Stable Identifier
R-HSA-2162188
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MDMQ10H2 is methylated to DMQ10H2 by COQ5
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial (COQ5) catalyses the C-methyltransferase conversion of 2-methoxy-6-decaprenyl-1,4-benzoquinol (MDMQ10H2) to 6-methoxy-3-methyl-2-decaprenyl-1,4-benzoquinol (DMQ10H2). This reaction is inferred from the equivalent reaction in yeast (Barkovich et al. 1997).

Literature References
PubMed ID Title Journal Year
9083049 Characterization of the COQ5 gene from Saccharomyces cerevisiae. Evidence for a C-methyltransferase in ubiquinone biosynthesis

Barkovich, RJ, Shtanko, A, Shepherd, JA, Lee, PT, Myles, DC, Tzagoloff, A, Clarke, CF

J Biol Chem 1997
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity of COQ5 [mitochondrial matrix]
Physical Entity
COQ5 [mitochondrial matrix]
Activity
2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity (0043430)
Inferred From
MDMQ6H2 is methylated to DMQ6H2 by Coq5 (Saccharomyces cerevisiae)
Cross References
Rhea
Authored
Williams, MG  (2012-03-19)
Reviewed
Kawamukai, M  (2013-02-05)
Created
Williams, MG  (2012-03-15)