MDMQ10H2 is methylated to DMQ10H2 by COQ5

Stable Identifier
R-HSA-2162188
Type
Reaction
Species
Homo sapiens
Compartment
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2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial (COQ5) catalyses the C-methyltransferase conversion of 2-methoxy-6-decaprenyl-1,4-benzoquinol (MDMQ10H2) to 6-methoxy-3-methyl-2-decaprenyl-1,4-benzoquinol (DMQ10H2). This reaction is inferred from the equivalent reaction in yeast (Barkovich et al. 1997).

Literature References
PubMed ID Title Journal Year
9083049 Characterization of the COQ5 gene from Saccharomyces cerevisiae. Evidence for a C-methyltransferase in ubiquinone biosynthesis

Tzagoloff, A, Shepherd, JA, Shtanko, A, Barkovich, RJ, Lee, PT, Myles, DC, Clarke, CF

J Biol Chem 1997
Participants
Participates
Catalyst Activity

2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity of COQ5 [mitochondrial matrix]

Inferred From
Cross References
Rhea
Authored
Reviewed
Created
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