abacavir + UDP-glucuronate => abacavir 5'-glucuronide + UDP

Stable Identifier
R-HSA-2162099
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
Synonyms
Glucuronidation of abacavir
ReviewStatus
5/5
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abacavir + UDP-glucuronate => abacavir 5'-glucuronide + UDP
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A member of the UDPGT (UDP-glucuronosyltransferase) enzyme family is thought to catalyze the reaction of abacavir and UDP-glucuronate to form UDP and abacavir-5'-glucuronate, one of the major forms in which abacavir is excreted from the body (McDowell et al. 1999; Ravitch and Moseley 2001). The specific UDPGT family enzyme family member or members that catalyze this reaction have not been identified.
Literature References
PubMed ID Title Journal Year
11678376 High-performance liquid chromatographic assay for abacavir and its two major metabolites in human urine and cerebrospinal fluid

Ravitch, JR, Moseley, CG

J Chromatogr B Biomed Sci Appl 2001
10582871 Pharmacokinetics of [(14)C]abacavir, a human immunodeficiency virus type 1 (HIV-1) reverse transcriptase inhibitor, administered in a single oral dose to HIV-1-infected adults: a mass balance study

McDowell, JA, Chittick, GE, Ravitch, JR, Polk, RE, Kerkering, TM, Stein, DS

Antimicrob Agents Chemother 1999
Participants
Input
Output
Participates
as an event of
Catalyst Activity

glucuronosyltransferase activity of UDPGT [endoplasmic reticulum membrane]

Physical Entity
UDPGT [endoplasmic reticulum membrane] (Homo sapiens)
Activity
glucuronosyltransferase activity (GO:0015020)
Authored
D'Eustachio, P  (2012-03-14)
Reviewed
Jassal, B  (2012-03-16)
Created
D'Eustachio, P  (2012-03-14)
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