Reactome | Arachidonate is hydroxylated to 20-HETE by CYP(3)

Arachidonate is hydroxylated to 20-HETE by CYP(3)

Stable Identifier

R-HSA-2161940

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, endoplasmic reticulum lumen

Synonyms

(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced (NADPH--hemoprotein reductase) => 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized (NADPH--hemoprotein reductase)

ReviewStatus

5/5

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Arachidonate is hydroxylated to 20-HETE by CYP(3)

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Several cytochrome P450s (CYPs) convert arachidonate to 20-hydroxyeicosatetraenoic acid (20-HETE). The CYPs and their references are as follows: CYP4A11 (Gainer et al. 2005, Powell 1998); CYP4F2 (Powell et al. 1998, Kikuta et al. 2002); CYP2U1 (Chuang et al. 2004); CYP1A1, CYP1A2, CYP1B1 (Choudhary et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
9618440	Metabolism of arachidonic acid to 20-hydroxy-5,8,11, 14-eicosatetraenoic acid by P450 enzymes in human liver: involvement of CYP4F2 and CYP4A11 Powell, PK, Wolf, I, Jin, R, Lasker, JM	J Pharmacol Exp Ther	1998
15611369	Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension Gainer, JV, Bellamine, A, Dawson, EP, Womble, KE, Grant, SW, Wang, Y, Cupples, LA, Guo, CY, Demissie, S, O'Donnell, CJ, Brown, NJ, Waterman, MR, Capdevila, JH	Circulation	2005
12432928	Prostaglandin and leukotriene omega-hydroxylases Kikuta, Y, Kusunose, E, Kusunose, M	Prostaglandins Other Lipid Mediat	2002
14660610	CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids Chuang, SS, Helvig, C, Taimi, M, Ramshaw, HA, Collop, AH, Amad, M, White, JA, Petkovich, M, Jones, G, Korczak, B	J Biol Chem	2004
15258110	Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1 Choudhary, D, Jansson, I, Stoilov, I, Sarfarazi, M, Schenkman, JB	Drug Metab Dispos	2004