Arachidonic acid is hydroxylated to 20-HETE by CYP(3)

Stable Identifier
Reaction [transition]
Homo sapiens
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Several cytochrome P450s (CYPs) convert arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE). The CYPs and their references are as follows: CYP4A11 (Gainer et al. 2005, Powell 1998); CYP4F2 (Powell et al. 1998, Kikuta et al. 2002); CYP2U1 (Chuang et al. 2004); CYP1A1, CYP1A2, CYP1B1 (Choudhary et al. 2004).

Literature References
PubMed ID Title Journal Year
9618440 Metabolism of arachidonic acid to 20-hydroxy-5,8,11, 14-eicosatetraenoic acid by P450 enzymes in human liver: involvement of CYP4F2 and CYP4A11

Jin, R, Lasker, JM, Powell, PK, Wolf, I

J Pharmacol Exp Ther 1998
15611369 Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension

Wang, Y, Dawson, EP, Cupples, LA, Bellamine, A, Brown, NJ, Demissie, S, Womble, KE, Gainer, JV, Guo, CY, Grant, SW, Capdevila, JH, Waterman, MR, O'Donnell, CJ

Circulation 2005
12432928 Prostaglandin and leukotriene omega-hydroxylases

Kikuta, Y, Kusunose, M, Kusunose, E

Prostaglandins Other Lipid Mediat 2002
14660610 CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids

Taimi, M, Helvig, C, Petkovich, M, Chuang, SS, Korczak, B, Ramshaw, HA, Jones, G, Collop, AH, Amad, M, White, JA

J Biol Chem 2004
15258110 Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1

Stoilov, I, Choudhary, D, Schenkman, JB, Sarfarazi, M, Jansson, I

Drug Metab Dispos 2004
Catalyst Activity

monooxygenase activity of CYP(3) [endoplasmic reticulum membrane]

Orthologous Events
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