Reactome | Arachidonate is epoxidated to 5,6-EET by CYP(4)

Arachidonate is epoxidated to 5,6-EET by CYP(4)

Stable Identifier

R-HSA-2161890

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

Synonyms

(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced (NADPH--hemoprotein reductase) => 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized (NADPH--hemoprotein reductase)

ReviewStatus

5/5

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Arachidonate is epoxidated to 5,6-EET by CYP(4)

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Several cytochrome P450s (CYPs) convert arachidonate to 5,6-epoxyeicosatrienoic acid (5,6-EET). The CYPs and their references are as follows: CYP1A1, CYP1A2, CYP1B1 (Choudhary et al. 2004); CYP2J2 (Wu et al. 1996).

Literature References

PubMed ID	Title	Journal	Year
8631948	Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart Wu, S, Moomaw, CR, Tomer, KB, Falck, JR, Zeldin, DC	J Biol Chem	1996
15258110	Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1 Choudhary, D, Jansson, I, Stoilov, I, Sarfarazi, M, Schenkman, JB	Drug Metab Dispos	2004