Reactome | EMILIN3 [extracellular region]

EMILIN3 [extracellular region]

Stable Identifier

R-HSA-2161272

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

EMILIN-3, EMIL3_HUMAN

Locations in the PathwayBrowser

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Extracellular matrix organization (Homo sapiens)

- Elastic fibre formation (Homo sapiens)
  - Molecules associated with elastic fibres (Homo sapiens)
    - Elastic fibres bind associated proteins (Homo sapiens)
      - Elastic fibre with associated proteins [extracellular region] (Homo sapiens)
        
        Elastic fibre:Fibulins:Emilins [extracellular region] (Homo sapiens)
        
        Emilins [extracellular region] (Homo sapiens)
        
        Emilin-3 polymer [extracellular region] (Homo sapiens)
        
        Emilin-3 trimer [extracellular region] (Homo sapiens)
        
        EMILIN3 [extracellular region] (Homo sapiens)
      - Elastic fibre:Fibulins:Emilins [extracellular region] (Homo sapiens)
        
        Emilins [extracellular region] (Homo sapiens)
        
        Emilin-3 polymer [extracellular region] (Homo sapiens)
        
        Emilin-3 trimer [extracellular region] (Homo sapiens)
        
        EMILIN3 [extracellular region] (Homo sapiens)
    - Emilin is found in elastic fibres (Homo sapiens)
      - Elastic fibre:Fibulins:Emilins [extracellular region] (Homo sapiens)
        
        Emilins [extracellular region] (Homo sapiens)
        
        Emilin-3 polymer [extracellular region] (Homo sapiens)
        
        Emilin-3 trimer [extracellular region] (Homo sapiens)
        
        EMILIN3 [extracellular region] (Homo sapiens)
      - Emilins [extracellular region] (Homo sapiens)
        
        Emilin-3 polymer [extracellular region] (Homo sapiens)
        
        Emilin-3 trimer [extracellular region] (Homo sapiens)
        
        EMILIN3 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NT22 EMILIN3

Gene Names

EMILIN3, C20orf130, EMILIN5

Chain

signal peptide:1-22, chain:23-766

Reference Genes

BioGPS Gene:90187 EMILIN3

COSMIC - genes:EMILIN3 EMILIN3

CTD Gene:90187 EMILIN3

dbSNP Gene:90187 EMILIN3

ENSEMBL:ENSG00000183798 EMILIN3

HGNC:16123 EMILIN3

KEGG:hsa:90187 EMILIN3

Monarch:90187 EMILIN3

NCBI Gene:90187 EMILIN3

OMIM:608929 EMILIN3

UCSC:Q9NT22 EMILIN3

Reference Transcript

RefSeq:NM_052846.2 EMILIN3

Other Identifiers

11727321_at

11727322_a_at

16919289

228307_PM_at

228307_at

3906130

3906131

3906132

3906133

3906134

3906135

3906136

3906139

3906140

3906142

3906143

3906144

43954_at

8066294

90187

A_23_P79816

GE80540

GO:0005198

GO:0005515

GO:0005576

GO:0005737

GO:0030023

GO:0030312

GO:0031012

GO:0042802

HMNXSV003007234

Hs.25897.0.S1_3p_at

ILMN_1795266

PH_hs_0031099

TC20000849.hg

Participates

as a component of

Emilin-3 trimer [extracellular region] (Homo sapiens)

Inferred To

EMILIN3 [extracellular region] (Bos taurus)

EMILIN3 [extracellular region] (Gallus gallus)

EMILIN3 [extracellular region] (Sus scrofa)

Emilin3 [extracellular region] (Mus musculus)

Emilin3 [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_443078.1

ENSEMBL

ENSG00000183798, ENST00000332312, ENSP00000332806

OpenTargets

ENSG00000183798

GeneCards

EMILIN3

HPA

ENSG00000183798-EMILIN3

PRO

Q9NT22

Pharos - Targets

Q9NT22

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O00560 SDCBP	3	SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206)	0.556	3
UniProt:Q9Y316 MEMO1	1	MEMO1 [cytosol] (R-HSA-6785630)	0.556	3
UniProt:P25054 APC	20	APC R213* [cytosol] (R-HSA-9666924) APC C1410* [cytosol] (R-HSA-9666925) APC K1310* [cytosol] (R-HSA-9666926) APC R499* [cytosol] (R-HSA-9666927) APC R1450* [cytosol] (R-HSA-5251499) APC G1357* [cytosol] (R-HSA-9666940) APC L1488* [cytosol] (R-HSA-9666941) APC S1400* [cytosol] (R-HSA-9666942) APC S1346* [cytosol] (R-HSA-9666943) APC R405* [cytosol] (R-HSA-9666936) APC S1281* [cytosol] (R-HSA-9666937) APC E1573* [cytosol] (R-HSA-9666938) APC R805* [cytosol] (R-HSA-9666939) APC R1386* [cytosol] (R-HSA-9666932) APC S1327* [cytosol] (R-HSA-9666933) APC E1209* [cytosol] (R-HSA-9666934) APC Q1469* [cytosol] (R-HSA-9666935) APC R564* [cytosol] (R-HSA-9666928) APC E1536* [cytosol] (R-HSA-9666929) APC G1288* [cytosol] (R-HSA-9666930)	0.527	2
UniProt:Q6VN20 RANBP10	1	RANBP10 [cytosol] (R-HSA-8851865)	0.527	2
UniProt:P09238 MMP10	2	MMP10(18-476) [extracellular region] (R-HSA-1604748) MMP10 [extracellular region] (R-HSA-1442488)	0.527	2
UniProt:Q13501 SQSTM1	7	SQSTM1 [cytosol] (R-HSA-193937) SQSTM1 [nucleoplasm] (R-HSA-210961) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711967)	0.527	2

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