abacavir + AMP => abacavir monophosphate + adenosine

Stable Identifier
R-HSA-2161193
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Phosphorylation of abacavir
ReviewStatus
5/5
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abacavir + AMP => abacavir monophosphate + adenosine
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Cytosolic adenosine phosphotransferase catalyzes the reaction of abacavir and AMP to form abacavir monophosphate and adenosine (Faletto et al. 1997). This enzymatic activity has been purified from human placenta and is distinct from known human kinases (Garvey and Krenitsky 1992) but has not been associated with a known human gene.
Literature References
PubMed ID Title Journal Year
1605627 A novel human phosphotransferase highly specific for adenosine

Garvey, EP, Krenitsky, TA

Arch Biochem Biophys 1992
9145876 Unique intracellular activation of the potent anti-human immunodeficiency virus agent 1592U89

Faletto, MB, Miller, WH, Garvey, EP, St Clair, MH, Daluge, SM, Good, SS

Antimicrob Agents Chemother 1997
Participants
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Output
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as an event of
Catalyst Activity

phosphotransferase activity, alcohol group as acceptor of adenosine phosphotransferase [cytosol]

Physical Entity
adenosine phosphotransferase [cytosol] (Homo sapiens)
Activity
phosphotransferase activity, alcohol group as acceptor (GO:0016773)
Authored
D'Eustachio, P  (2012-03-14)
Reviewed
Jassal, B  (2012-03-16)
Created
D'Eustachio, P  (2012-03-09)
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