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SMURF1 binds phosphorylated PARD6A
Stable Identifier
R-HSA-2160932
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cell junction
,
cytosol
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) (Homo sapiens)
SMURF1 binds phosphorylated PARD6A (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
SMURF1 ubiquitin ligase is recruited to tight junctions by binding to phosphorylated PARD6A (Ozdamar et al. 2005).
Literature References
PubMed ID
Title
Journal
Year
15761148
Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity
Barrios-Rodiles, M
,
Zhang, Y
,
Wrana, JL
,
Wang, HR
,
Bose, R
,
Ozdamar, B
Science
2005
Participants
Input
SMURF1 [cytosol]
(Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction]
(Homo sapiens)
Output
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane]
(Homo sapiens)
Participates
as an event of
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) (Homo sapiens)
Orthologous Events
SMURF1 binds phosphorylated PARD6A (Bos taurus)
SMURF1 binds phosphorylated PARD6A (Canis familiaris)
SMURF1 binds phosphorylated PARD6A (Danio rerio)
SMURF1 binds phosphorylated PARD6A (Drosophila melanogaster)
SMURF1 binds phosphorylated PARD6A (Mus musculus)
SMURF1 binds phosphorylated PARD6A (Rattus norvegicus)
SMURF1 binds phosphorylated PARD6A (Sus scrofa)
Authored
Orlic-Milacic, M (2012-04-05)
Reviewed
Huang, T (2012-05-14)
Created
Orlic-Milacic, M (2012-03-05)
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