Reactome | VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8

VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8

Stable Identifier

R-HSA-216076

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8

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Integrin alphaVbeta3 is highly expressed on osteoclasts, bone resorbing cells and is upregulated during vascular damage, angiogenesis and certain type of malignancies. It binds to vitronectin by recognizing the conserved RGD sequence within the N-terminal region. Integrin alphaVbeta3 plays an important role in signal transduction and regulation of osteoclast function. The integrin alphaVbeta5 receptor also interacts with vitronectin, promoting cell spreading. Integrin alphaVbeta8 can bind vitronectin as well as fibrin.

Literature References

PubMed ID	Title	Journal	Year
7685013	The alpha v beta 5 integrin receptor regulates receptor-mediated endocytosis of vitronectin Panetti, TS, McKeown-Longo, PJ	J. Biol. Chem.	1993
7559467	The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin Schnapp, LM, Hatch, N, Ramos, DM, Klimanskaya, IV, Sheppard, D, Pytela, R	J Biol Chem	1995
9251239	The alpha v beta 3 integrin "vitronectin receptor" Horton, MA	Int J Biochem Cell Biol	1997
7525578	Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain Nishimura, SL, Sheppard, D, Pytela, R	J Biol Chem	1994
9443892	The alphavbeta5 integrin functions as an endocytic receptor for vitronectin Memmo, LM, McKeown-Longo, P	J Cell Sci	1998
17968485	Involvement of alpha(v)beta3 integrins in osteoclast function Nakamura, I, Duong le, T, Rodan, SB, Rodan, GA	J Bone Miner Metab	2007