VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8

Stable Identifier
R-HSA-216076
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Integrin alphaVbeta3 is highly expressed on osteoclasts, bone resorbing cells and is upregulated during vascular damage, angiogenesis and certain type of malignancies. It binds to vitronectin by recognizing the conserved RGD sequence within the N-terminal region. Integrin alphaVbeta3 plays an important role in signal transduction and regulation of osteoclast function. The integrin alphaVbeta5 receptor also interacts with vitronectin, promoting cell spreading. Integrin alphaVbeta8 can bind vitronectin as well as fibrin.

Literature References
PubMed ID Title Journal Year
7559467 The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin

Schnapp, LM, Hatch, N, Ramos, DM, Klimanskaya, IV, Sheppard, D, Pytela, R

J Biol Chem 1995
7685013 The alpha v beta 5 integrin receptor regulates receptor-mediated endocytosis of vitronectin

Panetti, TS, McKeown-Longo, PJ

J. Biol. Chem. 1993
9251239 The alpha v beta 3 integrin "vitronectin receptor"

Horton, MA

Int J Biochem Cell Biol 1997
7525578 Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain

Nishimura, SL, Sheppard, D, Pytela, R

J Biol Chem 1994
9443892 The alphavbeta5 integrin functions as an endocytic receptor for vitronectin

Memmo, LM, McKeown-Longo, P

J Cell Sci 1998
17968485 Involvement of alpha(v)beta3 integrins in osteoclast function

Nakamura, I, Duong le, T, Rodan, SB, Rodan, GA

J Bone Miner Metab 2007
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