Interaction of integrin alphaDbeta2 with fibrin

Stable Identifier
R-HSA-216069
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Integrin alphaDbeta2 is a member of the beta2 family. It is expressed poorly on peripheral blood leukocytes but strongly on macrophages. alphaDbeta2 has the ability to interact with multiple ligands, including many ECM proteins. The interaction of beta2 integrins with ligands is mediated by their I-domains of the alpha subunits. The alphaD I-domain mediates the interaction with the ECM protein fibrinogen.

Literature References
PubMed ID Title Journal Year
16239428 Integrin alphaDbeta2, an adhesion receptor up-regulated on macrophage foam cells, exhibits multiligand-binding properties

Yakubenko, VP, Yadav, SP, Ugarova, TP

Blood 2006
10438935 The leukocyte integrin alpha D beta 2 binds VCAM-1: evidence for a binding interface between I domain and VCAM-1

Van der Vieren, M, Crowe, DT, Hoekstra, D, Vazeux, R, Hoffman, PA, Grayson, MH, Bochner, BS, Gallatin, WM, Staunton, DE

J Immunol 1999
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