Reactome | ITGA8(39-1063) [plasma membrane]

ITGA8(39-1063) [plasma membrane]

Stable Identifier

R-HSA-215943

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Integrin alpha-8

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by TGFB family members (Homo sapiens)
  - Signaling by TGF-beta Receptor Complex (Homo sapiens)
    - TGF-beta receptor signaling activates SMADs (Homo sapiens)
      - Latent TGF-beta-1 binds integrins (Homo sapiens)
        
        LAP1 binding-integrins [plasma membrane] (Homo sapiens)
        
        Integrin alpha8beta1 [plasma membrane] (Homo sapiens)
        
        ITGA8(39-1063) [plasma membrane] (Homo sapiens)
        
        LTBP1:TGFB1:LAP1:LAP1-binding integrins [plasma membrane] (Homo sapiens)
        
        LAP1 binding-integrins [plasma membrane] (Homo sapiens)
        
        Integrin alpha8beta1 [plasma membrane] (Homo sapiens)
        
        ITGA8(39-1063) [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P53708 ITGA8

Gene Names

ITGA8

Chain

signal peptide:1-38, chain:39-1063, chain:39-906, chain:907-1063

Reference Genes

BioGPS Gene:8516 ITGA8

COSMIC (genes):ITGA8 ITGA8

CTD Gene:8516 ITGA8

dbSNP Gene:8516 ITGA8

ENSEMBL:ENSG00000077943 ITGA8

ENSEMBL_homo_sapiens_GENE:ENSG00000077943.8 ITGA8

HGNC:6144 ITGA8

KEGG Gene (Homo sapiens):8516 ITGA8

Monarch:8516 ITGA8

NCBI Gene:8516 ITGA8

OMIM:604063 ITGA8

UCSC:P53708 ITGA8

Reference Transcript

RefSeq:NM_003638.2 ITGA8

Other Identifiers

11744251_a_at

16712086

214265_PM_at

214265_at

235666_PM_at

235666_at

242071_PM_x_at

242071_x_at

3279314

3279315

3279316

3279317

3279318

3279319

3279320

3279321

3279322

3279326

3279329

3279333

3279337

3279339

3279344

3279351

3279356

3279360

3279361

3279363

3279364

3279365

3279370

3279372

3279379

3279380

3279384

3279386

3279387

3279389

3279390

3279391

3279392

3279396

3279398

3279404

3279405

3279406

41005_at

77237_at

7932254

8516

92019_r_at

A_23_P46781

GE80823

GE88180

GO:0001656

GO:0001822

GO:0005178

GO:0005783

GO:0005886

GO:0005925

GO:0006351

GO:0006355

GO:0007155

GO:0007160

GO:0007179

GO:0007229

GO:0007399

GO:0007613

GO:0008305

GO:0009897

GO:0009986

GO:0016020

GO:0023052

GO:0030030

GO:0030154

GO:0030198

GO:0030511

GO:0032591

GO:0033627

GO:0034446

GO:0034678

GO:0042472

GO:0043204

GO:0043226

GO:0045177

GO:0045184

GO:0045944

GO:0046872

GO:0048333

GO:0048745

GO:0048856

GO:0050877

GO:0051145

GO:0098609

GO:0098839

GO:0098978

HMNXSV003044301

Hs.153717.0.A1_3p_at

Hs.171025.0.A1_3p_at

Hs.91296.0.A1_3p_at

ILMN_1660306

L36531_at

TC10001064.hg

Participates

as a component of

as an input of

Npnt binds ITGA8 (Homo sapiens)

Inferred To

ITGA8(39-1063) [plasma membrane] (Bos taurus)

ITGA8(39-1063) [plasma membrane] (Gallus gallus)

ITGA8(39-1063) [plasma membrane] (Mus musculus)

Itga8 [plasma membrane] (Rattus norvegicus)

if [plasma membrane] (Drosophila melanogaster)

ITGA8 [plasma membrane] (Canis familiaris)

ITGA8 [plasma membrane] (Sus scrofa)

pat-2 [plasma membrane] (Caenorhabditis elegans)

itga8 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_003629.2

Guide to Pharmacology - Targets

2447

OpenTargets

ENSG00000077943

GeneCards

P53708

HPA

ENSG00000077943-ITGA8

Ensembl

ENST00000378076, ENSG00000077943, ENSP00000367316

PRO

P53708

Pharos - Targets

P53708

Orphanet

22671

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UK85 DKKL1			0.527	2
UniProt:Q6UX41 BTNL8	1	BTNL8 [plasma membrane] (R-HSA-8852007)	0.527	2