Reactome | PEBP1 [cytosol]

PEBP1 [cytosol]

Stable Identifier

R-HSA-61487

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

RKIP, Phosphatidylethanolamine-binding protein (PEBP) (Neuropolypeptide h3) (Hippocampal cholinergic neurostimulating peptide) (HCNP) (Raf kinase inhibitor protein) (RKIP), Phosphatidylethanolamine-binding protein, PEBP, Prostatic binding protein, HCNPpp, Neuropolypeptide h3, Raf kinase inhibitor protein, Hippocampal cholinergic neurostimulating peptide, HCNP

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External Reference Information

External Reference

UniProt:P30086 PEBP1

Gene Names

PEBP1, PBP, PEBP

Chain

initiator methionine:1, chain:2-187, peptide:2-12

Reference Genes

BioGPS Gene:5037 PEBP1

COSMIC (genes):PEBP1 PEBP1

CTD Gene:5037 PEBP1

dbSNP Gene:5037 PEBP1

ENSEMBL:ENSG00000089220 PEBP1

HGNC:8630 PEBP1

KEGG Gene (Homo sapiens):5037 PEBP1

Monarch:5037 PEBP1

NCBI Gene:5037 PEBP1

OMIM:604591 PEBP1

UCSC:P30086 PEBP1

Reference Transcript

RefSeq:NM_002567.3 PEBP1

Other Identifiers

0000940487

11720526_s_at

16757710

205353_s_at

210825_s_at

211941_s_at

2449964

2449968

2562191

2562232

32611_at

3433797

3433798

3433803

3433805

3433808

3433809

3433810

5037

7959070

A_23_P13604

GE79047

GO:0000165

GO:0000166

GO:0003674

GO:0003723

GO:0004867

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0006464

GO:0007165

GO:0008150

GO:0008289

GO:0008429

GO:0010466

GO:0010951

GO:0019899

GO:0019901

GO:0030234

GO:0030414

GO:0043167

GO:0043226

GO:0043409

GO:0070062

HMNXSV003044456

Hs.80423.1.S1_3p_a_at

ILMN_1688089

PH_hs_0030191

PH_hs_0033329

TC12000926.hg

X75252_at

g4505620_3p_a_at

Participates

as an input of

PEBP1 binds activated RAF1 (Homo sapiens)

as a component of

p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)

Inferred To

PEBP1 [cytosol] (Bos taurus)

PEBP1 [cytosol] (Caenorhabditis elegans)

PEBP1 [cytosol] (Canis familiaris)

PEBP1 [cytosol] (Dictyostelium discoideum)

PEBP1 [cytosol] (Gallus gallus)

PEBP1 [cytosol] (Sus scrofa)

Homologues of PEBP1 [cytosol] (Canis familiaris)

Pebp1 [cytosol] (Mus musculus)

Pebp1 [cytosol] (Rattus norvegicus)

pebp1 [cytosol] (Danio rerio)

BcDNA:GH28351 [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_002558.1

Target Pathogen

5b354852be737e166372eb9d

OpenTargets

ENSG00000089220

GeneCards

P30086

HPA

ENSG00000089220-PEBP1

Ensembl

ENSG00000089220, ENSP00000261313, ENST00000261313

PRO

P30086

PDB

1BD9, 2QYQ, 1BEH, 2L7W

HMDB Protein

HMDBP07304

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04049 RAF1	54	p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098) p-S621-RAF1 G361A [cytosol] (R-HSA-9656092) p-S621-RAF1 G370R [cytosol] (R-HSA-9656094) p-S621-RAF1 D486G [cytosol] (R-HSA-9656085) p-S621-RAF1 T491R [cytosol] (R-HSA-9656145) p-S338,Y341,T492,S494,S621 RAF1 D486N [cytosol] (R-HSA-9656026) p-S338,Y341,T492,S494,S621 RAF1 S427G [cytosol] (R-HSA-9656070) p-S338,Y341,T492,S494,S621 RAF1 L613V [cytosol] (R-HSA-9656035) p-S338,Y341,S494,S621-RAF1 T491I [cytosol] (R-HSA-9656019) p-S338,Y341,T492,S494,S621 RAF1 G361A [cytosol] (R-HSA-9656029) p-S338,Y341,T492,S494,S621 RAF1 G370R [cytosol] (R-HSA-9656031) p-S338,Y341,T492,S494,S621 RAF1 D486G [cytosol] (R-HSA-9656023) p-S338,Y341,S494,S621 RAF1 T491R [cytosol] (R-HSA-9656017) p-S338,Y341,T492,S494,S621 RAF1 S259F [cytosol] (R-HSA-9656062) p-S338,Y341,T492,S494,S621 RAF1 P261A [cytosol] (R-HSA-9656041) p-S338,Y341,T492,S494,S621 RAF1 S257L [cytosol] (R-HSA-9656058) p-S338,Y341,T492,S494,S621 RAF1 P261L [cytosol] (R-HSA-9656043) p-S338,Y341,T492,S494,S621 RAF1 P261T [cytosol] (R-HSA-9656053) p-S338,Y341,T492,S494,S621 RAF1 N262K [cytosol] (R-HSA-9656037) p-S338,Y341,T492,S494,S621 RAF1 P261S [cytosol] (R-HSA-9656050) p-S338,Y341,T492,S494,S621 RAF1 S259T [cytosol] (R-HSA-9656067) p-S338,Y341,T492,S494,S621 RAF1 T260R [cytosol] (R-HSA-9656077) p-S338,Y341,T492,S494,S621 RAF1 P261R [cytosol] (R-HSA-9656047) p-S338,Y341,T492,S494,S621 RAF1 R256S [cytosol] (R-HSA-9656056) p-S338,Y341,T492,S494,S621 RAF1 T260I [cytosol] (R-HSA-9656074) p-S338,Y341,T492,S494,S621 RAF1 V263A [cytosol] (R-HSA-9656080) p-S338,Y341,T492,S494,S621 RAF1 S259P [cytosol] (R-HSA-9656065) RAF1 [cytosol] (R-HSA-167205) p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 [plasma membrane] (R-HSA-206222) p-Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5675420) p-S259,S621-RAF1 [cytosol] (R-HSA-109786) hyperphosphorylated RAF1 [plasma membrane] (R-HSA-5675193) p-S621-RAF1 [cytosol] (R-HSA-206028) p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5672665) p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (R-HSA-5672664)	0.758	10
UniProt:Q9JLL3 TNR19			0.602	4
UniProt:Q9NRD5 PICK1	2	PICK1 [endocytic vesicle membrane] (R-HSA-417017) PICK1 [plasma membrane] (R-HSA-416989)	0.556	3
UniProt:Q15208 STK38	1	STK38 [cytosol] (R-HSA-9715143)	0.499	3
UniProt:P16050 ALOX15	1	ALOX15 [cytosol] (R-HSA-2142838)	0.499	3
UniProt:Q9NS68 TNR19			0.463	4

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