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PEBP1 [cytosol]
Stable Identifier
R-HSA-61487
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
RKIP, Phosphatidylethanolamine-binding protein (PEBP) (Neuropolypeptide h3) (Hippocampal cholinergic neurostimulating peptide) (HCNP) (Raf kinase inhibitor protein) (RKIP), Phosphatidylethanolamine-binding protein, PEBP, Prostatic binding protein, HCNPpp, Neuropolypeptide h3, Raf kinase inhibitor protein, Hippocampal cholinergic neurostimulating peptide, HCNP
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs (Homo sapiens)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
PEBP1 [cytosol] (Homo sapiens)
Signaling by BRAF and RAF1 fusions (Homo sapiens)
p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs (Homo sapiens)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
PEBP1 [cytosol] (Homo sapiens)
Signaling by RAS mutants (Homo sapiens)
Signaling downstream of RAS mutants (Homo sapiens)
Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
PEBP1 [cytosol] (Homo sapiens)
Signaling by high-kinase activity BRAF mutants (Homo sapiens)
High kinase activity BRAF mutants bind MAP2Ks and MAPKs (Homo sapiens)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
PEBP1 [cytosol] (Homo sapiens)
Signaling by moderate kinase activity BRAF mutants (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
PEBP1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
MAP2K and MAPK activation (Homo sapiens)
MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)
PEBP1 [cytosol] (Homo sapiens)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
PEBP1 [cytosol] (Homo sapiens)
Negative regulation of MAPK pathway (Homo sapiens)
PEBP1 binds activated RAF1 (Homo sapiens)
PEBP1 [cytosol] (Homo sapiens)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
PEBP1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P30086 PEBP1
Gene Names
PEBP1, PBP, PEBP
Chain
initiator methionine:1, chain:2-187, peptide:2-12
Reference Genes
BioGPS Gene:5037 PEBP1
COSMIC (genes):PEBP1 PEBP1
CTD Gene:5037 PEBP1
dbSNP Gene:5037 PEBP1
ENSEMBL:ENSG00000089220 PEBP1
HGNC:8630 PEBP1
KEGG Gene (Homo sapiens):5037 PEBP1
Monarch:5037 PEBP1
NCBI Gene:5037 PEBP1
OMIM:604591 PEBP1
UCSC:P30086 PEBP1
Reference Transcript
RefSeq:NM_002567.3 PEBP1
Other Identifiers
0000940487
11720526_s_at
16757710
205353_PM_s_at
205353_s_at
210825_PM_s_at
210825_s_at
211941_PM_s_at
211941_s_at
2449964
2449968
2562191
2562232
32611_at
3433797
3433798
3433803
3433805
3433808
3433809
3433810
5037
7959070
A_23_P13604
GE79047
GO:0000166
GO:0003674
GO:0003723
GO:0004867
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005737
GO:0005829
GO:0007165
GO:0008150
GO:0008289
GO:0008429
GO:0010466
GO:0010951
GO:0019899
GO:0019901
GO:0030234
GO:0030414
GO:0043167
GO:0043226
GO:0043409
GO:0070062
HMNXSV003044456
Hs.80423.1.S1_3p_a_at
ILMN_1688089
PH_hs_0030191
PH_hs_0033329
TC12000926.hg
X75252_at
g4505620_3p_a_at
Participates
as an input of
PEBP1 binds activated RAF1 (Homo sapiens)
as a component of
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
Inferred To
Dmel\CG7054 [cytosol]
(Drosophila melanogaster)
PEBP1 [cytosol]
(Bos taurus)
PEBP1 [cytosol]
(Caenorhabditis elegans)
PEBP1 [cytosol]
(Canis familiaris)
PEBP1 [cytosol]
(Gallus gallus)
PEBP1 [cytosol]
(Sus scrofa)
Homologues of PEBP1 [cytosol]
(Caenorhabditis elegans)
Homologues of PEBP1 [cytosol]
(Canis familiaris)
Homologues of PEBP1 [cytosol]
(Drosophila melanogaster)
Pebp1 [cytosol]
(Drosophila melanogaster)
Pebp1 [cytosol]
(Mus musculus)
Pebp1 [cytosol]
(Rattus norvegicus)
pebp1 [cytosol]
(Danio rerio)
Dmel\CG17919 [cytosol]
(Drosophila melanogaster)
a5 [cytosol]
(Drosophila melanogaster)
BcDNA:GH28351 [cytosol]
(Drosophila melanogaster)
Dmel\CG17917 [cytosol]
(Drosophila melanogaster)
Dmel\CG6180 [cytosol]
(Drosophila melanogaster)
pebp1.1 [cytosol]
(Xenopus tropicalis)
anon-SAGE:Wang-129 [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_002558.1
OpenTargets
ENSG00000089220
GeneCards
P30086
HPA
ENSG00000089220-PEBP1
Ensembl
ENSP00000261313
,
ENST00000261313
,
ENSG00000089220
PRO
P30086
Pharos - Targets
P30086
HMDB Protein
HMDBP07304
PDB
1BEH
,
2QYQ
,
1BD9
,
2L7W
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04049 RAF1
20
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
p-S621-RAF1 G361A [cytosol]
(R-HSA-9656092)
p-S621-RAF1 G370R [cytosol]
(R-HSA-9656094)
0.758
10
UniProt:Q9JLL3 TNR19
0.602
4
UniProt:Q9NRD5 PICK1
2
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
PICK1 [plasma membrane]
(R-HSA-416989)
0.556
3
UniProt:Q15208 STK38
1
STK38 [cytosol]
(R-HSA-9715143)
0.499
3
UniProt:P16050 ALOX15
1
ALOX15 [cytosol]
(R-HSA-2142838)
0.499
3
UniProt:Q9NS68 TNR19
0.463
4
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