Aflatoxins are produced by the fungal molds Aspergillus flavus and Aspergillus parasiticus. Dietary contamination accounts for adverse health problems including liver cancer therby classifying aflatoxins as Group 1 carcinogens in humans. The B1 form of aflatoxin (AFB1) is especially carcinogenic in a number of species including humans.AFB1 requires microsomal oxidation to produce epoxides which are the cause of their toxic and carcinogenic effects. In humans, both CYP3A4 and CYP3A5 are able to produce epoxide stereoisomers of AFB1, the most potent being aflatoxin B1 exo-8,9-oxide (AFXBO) (Gallagher et al. 1996).
Eaton, DL, Stapleton, PL, Kunze, KL, Gallagher, EP
Kirk, G, Mendy, M, Hustert, E, Whittle, HC, Pedersen, B, Brockmöller, J, Wild, CP, Wojnowski, L, Turner, PC
monooxygenase activity of Cytochrome P450 (CYP3A5 based) [endoplasmic reticulum membrane]
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