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HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [lysosomal membrane]
Stable Identifier
R-HSA-2130676
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
lysosomal membrane
Synonyms
2B31_HUMAN, HLA-DRB3
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
MHC class II antigen presentation (Homo sapiens)
Cleavage of lip22 to lip10 (Homo sapiens)
MHC II:lip10 nonamer [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [lysosomal membrane] (Homo sapiens)
MHC II:lip22 nonamer [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [lysosomal membrane] (Homo sapiens)
Disassociation of CLIP from MHC II (Homo sapiens)
MHC II:CLIP [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [lysosomal membrane] (Homo sapiens)
peptide free MHC II:HLA-DM [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [lysosomal membrane] (Homo sapiens)
Generation of CLIP from lip10 (Homo sapiens)
MHC II:CLIP [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [lysosomal membrane] (Homo sapiens)
MHC II:lip10 nonamer [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [lysosomal membrane] (Homo sapiens)
Initial proteolyis of Ii by aspartic proteases to lip22 (Homo sapiens)
MHC II:lip22 nonamer [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [lysosomal membrane] (Homo sapiens)
Nonameric complex [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [lysosomal membrane] (Homo sapiens)
Loading of antigenic peptides (Homo sapiens)
peptide free MHC II:HLA-DM [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [lysosomal membrane] (Homo sapiens)
peptide loaded MHC class II [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [lysosomal membrane] (Homo sapiens)
TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Homo sapiens)
Nonameric complex [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [lysosomal membrane] (Homo sapiens)
Trafficking of nonameric complex in the endocytic pathway (Homo sapiens)
Nonameric complex [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [lysosomal membrane] (Homo sapiens)
Transport of antigen loaded MHC II molecules to surface (Homo sapiens)
peptide loaded MHC class II [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [lysosomal membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P79483 HLA-DRB3
Gene Names
HLA-DRB3
Chain
signal peptide:1-29, chain:30-266
Reference Genes
BioGPS Gene:3125 HLA-DRB3
CTD Gene:3125 HLA-DRB3
dbSNP Gene:3125 HLA-DRB3
ENSEMBL:ENSG00000196101 HLA-DRB3
HGNC:4951 HLA-DRB3
KEGG:hsa:3125 HLA-DRB3
Monarch:3125 HLA-DRB3
NCBI Gene:3125 HLA-DRB3
OMIM:612735 HLA-DRB3
UCSC:P79483 HLA-DRB3
Reference Transcript
RefSeq:NM_022555.3 HLA-DRB3
Other Identifiers
11723194_x_at
11759642_x_at
17027082
17029705
17039907
215193_PM_x_at
215193_x_at
2950021
2950023
2950025
2950027
2950032
2950033
2950035
2950052
2950057
2950060
3125
4048258
4048272
4048275
4048282
4048284
41723_s_at
8178802
8178811
8180003
A_23_P145336
A_24_P402222
GE532983
GO:0000139
GO:0002250
GO:0002376
GO:0002469
GO:0002503
GO:0002504
GO:0002842
GO:0005515
GO:0005764
GO:0005765
GO:0005768
GO:0005773
GO:0005783
GO:0005789
GO:0005886
GO:0006955
GO:0007165
GO:0010008
GO:0012507
GO:0016020
GO:0019882
GO:0019886
GO:0023026
GO:0030658
GO:0030666
GO:0030669
GO:0031410
GO:0031902
GO:0032395
GO:0032588
GO:0042605
GO:0042613
GO:0043226
GO:0050778
GO:0050852
GO:0050870
GO:0060089
GO:0065003
GO:0098553
GO:0120281
GO:2000516
HMNXSV003044723
Hs.279930.1.S1_3p_x_at
ILMN_1717261
TC6_apd_hap1000101.hg
TC6_dbb_hap3000208.hg
TC6_ssto_hap7000164.hg
Participates
as a member of
HLA II beta chain [lysosomal membrane] (Homo sapiens)
Other forms of this molecule
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [lumenal side of endoplasmic reticulum membrane]
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [ER to Golgi transport vesicle membrane]
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [Golgi membrane]
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [trans-Golgi network membrane]
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [transport vesicle membrane]
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [clathrin-coated endocytic vesicle membrane]
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [endocytic vesicle membrane]
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [plasma membrane]
Inferred To
H2-Eb1 [lysosomal membrane]
(Mus musculus)
b2m [lysosomal membrane]
(Danio rerio)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [lysosomal membrane]
(Danio rerio)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [lysosomal membrane]
(Mus musculus)
RT1-Db1 [lysosomal membrane]
(Rattus norvegicus)
mhc2-dab [lysosomal membrane]
(Xenopus tropicalis)
H2-Eb2 [lysosomal membrane]
(Mus musculus)
LOC100153139 [lysosomal membrane]
(Sus scrofa)
zmp:0000001138 [lysosomal membrane]
(Danio rerio)
HLA class II histocompatibility antigen, DR beta 4 chain [lysosomal membrane]
(Bos taurus)
Cross References
RefSeq
NP_072049.2
ENSEMBL
ENSP00000372607
,
ENST00000383126
,
ENST00000307137
,
ENSP00000302517
ZINC - Substances
DRB3_HUMAN
ZINC target
P79483
PRO
P79483
ZINC - Predictions - Purchasable
DRB3_HUMAN
PDB
4H1L
,
2Q6W
,
3C5J
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P36957 DLST
5
Lipo-K110-DLST [mitochondrial matrix]
(R-HSA-69993)
SuccinyllipoH2-K110-DLST [mitochondrial matrix]
(R-HSA-9853502)
LipoH2-K110-DLST [mitochondrial matrix]
(R-HSA-9853485)
DLST [mitochondrial matrix]
(R-HSA-6792574)
GlutaryllipoH2-K110-DLST [mitochondrial matrix]
(R-HSA-9858581)
0.556
3
UniProt:P27797 CALR
6
CALR [lumenal side of endoplasmic reticulum membrane]
(R-HSA-985502)
CALR [endoplasmic reticulum lumen]
(R-HSA-195905)
CALR [extracellular region]
(R-HSA-2197641)
CALR [endocytic vesicle lumen]
(R-HSA-2239448)
CALR [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-8863866)
CALR [phagocytic vesicle membrane]
(R-HSA-1236879)
0.556
3
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