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HLA class II histocompatibility antigen, DR beta 5 chain [lysosomal membrane]
Stable Identifier
R-HSA-2130591
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
lysosomal membrane
Synonyms
HLA-DRB5, DRB5_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
MHC class II antigen presentation (Homo sapiens)
Cleavage of lip22 to lip10 (Homo sapiens)
MHC II:lip10 nonamer [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 5 chain [lysosomal membrane] (Homo sapiens)
MHC II:lip22 nonamer [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 5 chain [lysosomal membrane] (Homo sapiens)
Disassociation of CLIP from MHC II (Homo sapiens)
MHC II:CLIP [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 5 chain [lysosomal membrane] (Homo sapiens)
peptide free MHC II:HLA-DM [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 5 chain [lysosomal membrane] (Homo sapiens)
Generation of CLIP from lip10 (Homo sapiens)
MHC II:CLIP [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 5 chain [lysosomal membrane] (Homo sapiens)
MHC II:lip10 nonamer [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 5 chain [lysosomal membrane] (Homo sapiens)
Initial proteolyis of Ii by aspartic proteases to lip22 (Homo sapiens)
MHC II:lip22 nonamer [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 5 chain [lysosomal membrane] (Homo sapiens)
Nonameric complex [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 5 chain [lysosomal membrane] (Homo sapiens)
Loading of antigenic peptides (Homo sapiens)
peptide free MHC II:HLA-DM [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 5 chain [lysosomal membrane] (Homo sapiens)
peptide loaded MHC class II [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 5 chain [lysosomal membrane] (Homo sapiens)
TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Homo sapiens)
Nonameric complex [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 5 chain [lysosomal membrane] (Homo sapiens)
Trafficking of nonameric complex in the endocytic pathway (Homo sapiens)
Nonameric complex [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 5 chain [lysosomal membrane] (Homo sapiens)
Transport of antigen loaded MHC II molecules to surface (Homo sapiens)
peptide loaded MHC class II [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 5 chain [lysosomal membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q30154 HLA-DRB5
Gene Names
HLA-DRB5
Chain
signal peptide:1-29, chain:30-266
Reference Genes
BioGPS Gene:3127 HLA-DRB5
COSMIC (genes):HLA-DRB5 HLA-DRB5
CTD Gene:3127 HLA-DRB5
dbSNP Gene:3127 HLA-DRB5
ENSEMBL:ENSG00000198502 HLA-DRB5
HGNC:4953 HLA-DRB5
KEGG:hsa:3127 HLA-DRB5
Monarch:3127 HLA-DRB5
NCBI Gene:3127 HLA-DRB5
OMIM:604776 HLA-DRB5
UCSC:Q30154 HLA-DRB5
Reference Transcript
RefSeq:NM_002125.3 HLA-DRB5
Other Identifiers
11720657_x_at
17017885
215193_PM_x_at
215193_x_at
2950023
2950025
2950033
2950046
2950057
2950060
2950067
3127
4048242
4048243
4048245
4048247
4048248
4048249
4048251
4048252
4048253
4048256
4048257
4048258
4048272
4048288
8125436
A_23_P45099
GE88565
GO:0000139
GO:0002250
GO:0002376
GO:0002503
GO:0002504
GO:0005515
GO:0005764
GO:0005765
GO:0005768
GO:0005773
GO:0005783
GO:0005789
GO:0005794
GO:0005886
GO:0006955
GO:0010008
GO:0012507
GO:0016020
GO:0019882
GO:0019886
GO:0023026
GO:0030658
GO:0030666
GO:0030669
GO:0031410
GO:0031902
GO:0032588
GO:0042605
GO:0042613
GO:0043226
GO:0050778
GO:0050870
GO:0065003
GO:0070062
GO:0098553
HMNXSV003053454
Hs.279930.1.S1_3p_x_at
ILMN_1697499
TC06004122.hg
TC6_dbb_hap3000180.hg
Participates
as a member of
HLA II beta chain [lysosomal membrane] (Homo sapiens)
Other forms of this molecule
HLA class II histocompatibility antigen, DR beta 5 chain [lumenal side of endoplasmic reticulum membrane]
HLA class II histocompatibility antigen, DR beta 5 chain [ER to Golgi transport vesicle membrane]
HLA class II histocompatibility antigen, DR beta 5 chain [Golgi membrane]
HLA class II histocompatibility antigen, DR beta 5 chain [trans-Golgi network membrane]
HLA class II histocompatibility antigen, DR beta 5 chain [transport vesicle membrane]
HLA class II histocompatibility antigen, DR beta 5 chain [clathrin-coated endocytic vesicle membrane]
HLA class II histocompatibility antigen, DR beta 5 chain [endocytic vesicle membrane]
HLA class II histocompatibility antigen, DR beta 5 chain [plasma membrane]
Inferred To
H2-Eb1 [lysosomal membrane]
(Mus musculus)
b2m [lysosomal membrane]
(Danio rerio)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [lysosomal membrane]
(Bos taurus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [lysosomal membrane]
(Danio rerio)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [lysosomal membrane]
(Mus musculus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [lysosomal membrane]
(Rattus norvegicus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [lysosomal membrane]
(Sus scrofa)
RT1-Db1 [lysosomal membrane]
(Rattus norvegicus)
mhc2-dab [lysosomal membrane]
(Xenopus tropicalis)
H2-Eb2 [lysosomal membrane]
(Mus musculus)
LOC100153139 [lysosomal membrane]
(Sus scrofa)
RT1-Db2 [lysosomal membrane]
(Rattus norvegicus)
SLA-DRB1 [lysosomal membrane]
(Sus scrofa)
zmp:0000001138 [lysosomal membrane]
(Danio rerio)
HLA class II histocompatibility antigen, DR beta 4 chain [lysosomal membrane]
(Bos taurus)
HLA class II histocompatibility antigen, DR beta 4 chain [lysosomal membrane]
(Sus scrofa)
Cross References
RefSeq
NP_002116.2
ENSEMBL
ENST00000374975
,
ENSP00000364114
OpenTargets
ENSG00000198502
HPA
ENSG00000198502-HLA-DRB5
PRO
Q30154
Pharos - Targets
Q30154
PDB
1H15
,
1ZGL
,
1FV1
,
1HQR
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O14757 CHEK1
3
p-S317,S345-CHEK1 [nucleoplasm]
(R-HSA-113838)
CHEK1 [nucleoplasm]
(R-HSA-113826)
CHEK1 [cytosol]
(R-HSA-205285)
0.564
2
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