STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7

Stable Identifier
R-HSA-2128994
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7
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STRAP binds both TGF-beta receptor and SMAD7, and stabilizes interaction of phosphorylated TGF-beta receptor complex with SMAD7.This reaction may involve oligomerization of STRAP. STRAP and SMAD7 act synergistically to inhibit the transcription of TGF-beta target genes by preventing SMAD2 and SMAD3 from binding phosphorylated TGFBR1.
Literature References
PubMed ID Title Journal Year
10757800 STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling

Datta, PK, Moses, HL

Mol Cell Biol 2000
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Orthologous Events
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Authored
Orlic-Milacic, M  (2012-04-05)
Reviewed
Huang, T  (2012-05-14)
Created
Orlic-Milacic, M  (2012-02-18)
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