CYP26A1,B1 4-hydroxylate atRA

Stable Identifier
R-HSA-212007
Type
Reaction [transition]
Species
Homo sapiens
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Retinoic acid (RA) is a biologically active analogue of vitamin A (retinol). RA plays an important role in regulating cell growth and differentiation.CYP26A1 is involved in the metabolic breakdown of RA by 4-hydroxylation. CYP26A1-mediated 4-hydroxylation is specific for all-trans-RA but not for the isomers 13-cis-RA and 9-cis-RA (Sonneveld et al. 1998). CYP26B1 can also deactivate all-trans-retinoic acid by 4-hydroxylation. High expression levels in the cerebellum and pons of human brain suggests a protective role of specific tissues against retinoid damage (White et al. 2000).

Literature References
PubMed ID Title Journal Year
9716180 Human retinoic acid (RA) 4-hydroxylase (CYP26) is highly specific for all-trans-RA and can be induced through RA receptors in human breast and colon carcinoma cells

Sonneveld, E, van den Brink, CE, van der Leede, BM, Schulkes, RK, Petkovich, M, van der Burg, B, van der Saag, PT

Cell Growth Differ 1998
10823918 Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-trans-retinoic acid metabolism

White, JA, Ramshaw, H, Taimi, M, Stangle, W, Zhang, A, Everingham, S, Creighton, S, Tam, SP, Jones, G, Petkovich, M

Proc Natl Acad Sci U S A 2000
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hasEvent
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Title
retinoic acid 4-hydroxylase activity of CYP26A1,B1,C1 [endoplasmic reticulum membrane]
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