Reactome | CYP26A1,B1 4-hydroxylate atRA

CYP26A1,B1 4-hydroxylate atRA

Stable Identifier

R-HSA-212007

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

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Retinoic acid (RA) is a biologically active analogue of vitamin A (retinol). RA plays an important role in regulating cell growth and differentiation.CYP26A1 is involved in the metabolic breakdown of RA by 4-hydroxylation. CYP26A1-mediated 4-hydroxylation is specific for all-trans-RA but not for the isomers 13-cis-RA and 9-cis-RA (Sonneveld et al. 1998). CYP26B1 can also deactivate all-trans-retinoic acid by 4-hydroxylation. High expression levels in the cerebellum and pons of human brain suggests a protective role of specific tissues against retinoid damage (White et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
9716180	Human retinoic acid (RA) 4-hydroxylase (CYP26) is highly specific for all-trans-RA and can be induced through RA receptors in human breast and colon carcinoma cells Sonneveld, E, van den Brink, CE, van der Leede, BM, Schulkes, RK, Petkovich, M, van der Burg, B, van der Saag, PT	Cell Growth Differ	1998
10823918	Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-trans-retinoic acid metabolism White, JA, Ramshaw, H, Taimi, M, Stangle, W, Zhang, A, Everingham, S, Creighton, S, Tam, SP, Jones, G, Petkovich, M	Proc Natl Acad Sci U S A	2000