Retinoic acid (RA) is a biologically active analogue of vitamin A (retinol). RA plays an important role in regulating cell growth and differentiation.CYP26A1 is involved in the metabolic breakdown of RA by 4-hydroxylation. CYP26A1-mediated 4-hydroxylation is specific for all-trans-RA but not for the isomers 13-cis-RA and 9-cis-RA (Sonneveld et al. 1998). CYP26B1 can also deactivate all-trans-retinoic acid by 4-hydroxylation. High expression levels in the cerebellum and pons of human brain suggests a protective role of specific tissues against retinoid damage (White et al. 2000).
Sonneveld, E, van den Brink, CE, van der Leede, BM, Schulkes, RK, Petkovich, M, van der Burg, B, van der Saag, PT
White, JA, Ramshaw, H, Taimi, M, Stangle, W, Zhang, A, Everingham, S, Creighton, S, Tam, SP, Jones, G, Petkovich, M
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