Reactome | CYP2F1 dehydrogenates 3-methylindole

CYP2F1 dehydrogenates 3-methylindole

Stable Identifier

R-HSA-212005

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, endoplasmic reticulum lumen

ReviewStatus

5/5

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3-methylindole (3MI) is a fermentation product of tryptophan. It is usually formed in the rumen of goats and cattle and in the large intestine of humans. CYP2F1 shows the highest activity towards the dehydrogenation of 3MI to form a methylene imine-reactive intermediate.

Literature References

PubMed ID	Title	Journal	Year
10383923	Specific dehydrogenation of 3-methylindole and epoxidation of naphthalene by recombinant human CYP2F1 expressed in lymphoblastoid cells Yost, GS, Code, E, Gonzalez, FJ, Lanza, DL, Crespi, CL	Drug Metab Dispos	1999