CYP2F1 dehydrogenates 3-methylindole

Stable Identifier
R-HSA-212005
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, endoplasmic reticulum lumen
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CYP2F1 dehydrogenates 3-methylindole
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3-methylindole (3MI) is a fermentation product of tryptophan. It is usually formed in the rumen of goats and cattle and in the large intestine of humans. CYP2F1 shows the highest activity towards the dehydrogenation of 3MI to form a methylene imine-reactive intermediate.

Literature References
PubMed ID Title Journal Year
10383923 Specific dehydrogenation of 3-methylindole and epoxidation of naphthalene by recombinant human CYP2F1 expressed in lymphoblastoid cells

Lanza, DL, Code, E, Crespi, CL, Gonzalez, FJ, Yost, GS

Drug Metab Dispos 1999
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
monooxygenase activity of Cytochrome P450 (CYP2F1 based) [endoplasmic reticulum membrane]
Physical Entity
Cytochrome P450 (CYP2F1 based) [endoplasmic reticulum membrane]
Activity
monooxygenase activity (0004497)
Orthologous Events
CYP2F1 dehydrogenates 3-methylindole (Bos taurus)
CYP2F1 dehydrogenates 3-methylindole (Caenorhabditis elegans)
CYP2F1 dehydrogenates 3-methylindole (Canis familiaris)
CYP2F1 dehydrogenates 3-methylindole (Danio rerio)
CYP2F1 dehydrogenates 3-methylindole (Dictyostelium discoideum)
CYP2F1 dehydrogenates 3-methylindole (Mus musculus)
CYP2F1 dehydrogenates 3-methylindole (Rattus norvegicus)
CYP2F1 dehydrogenates 3-methylindole (Sus scrofa)
CYP2F1 dehydrogenates 3-methylindole (Xenopus tropicalis)
Authored
Jassal, B  (2008-05-19)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2008-02-08)
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