Phenytoin is a widely used anti-epileptic drug which can be hydroxylated by several P450s including CYP2C18 to its major metabolite, (5-(4-hydroxyphenyl)-phenylhydantoin (HPPH).
Gillam, EM, Mitchell, DJ, Kinobe, RT, Parkinson, OT
monooxygenase activity of Cytochrome P450 (CYP2C18 based) [endoplasmic reticulum membrane]
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