CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation

Stable Identifier
R-HSA-212004
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, endoplasmic reticulum lumen
ReviewStatus
5/5
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CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation
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Phenytoin is a widely used anti-epileptic drug which can be hydroxylated by several P450s including CYP2C18 to its major metabolite, (5-(4-hydroxyphenyl)-phenylhydantoin (HPPH).
Literature References
PubMed ID Title Journal Year
16359177 P450 2C18 catalyzes the metabolic bioactivation of phenytoin

Gillam, EM, Mitchell, DJ, Kinobe, RT, Parkinson, OT

Chem Res Toxicol 2005
Participants
Input
Output
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as an event of
Catalyst Activity

monooxygenase activity of Cytochrome P450 (CYP2C18 based) [endoplasmic reticulum membrane]

Physical Entity
Cytochrome P450 (CYP2C18 based) [endoplasmic reticulum membrane] (Homo sapiens)
Activity
monooxygenase activity (GO:0004497)
Orthologous Events
CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Bos taurus)
CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Caenorhabditis elegans)
CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Dictyostelium discoideum)
CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Drosophila melanogaster)
CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Gallus gallus)
CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Mus musculus)
CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Rattus norvegicus)
CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Sus scrofa)
Authored
Jassal, B  (2008-05-19)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2008-02-08)
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