CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation

Stable Identifier
R-HSA-212004
Type
Reaction
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, endoplasmic reticulum lumen
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CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation
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Phenytoin is a widely used anti-epileptic drug which can be hydroxylated by several P450s including CYP2C18 to its major metabolite, (5-(4-hydroxyphenyl)-phenylhydantoin (HPPH).

Literature References
PubMed ID Title Journal Year
16359177 P450 2C18 catalyzes the metabolic bioactivation of phenytoin

Gillam, EM, Mitchell, DJ, Kinobe, RT, Parkinson, OT

Chem Res Toxicol 2005
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Output
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as an event of
Catalyst Activity

monooxygenase activity of Cytochrome P450 (CYP2C18 based) [endoplasmic reticulum membrane]

Physical Entity
Cytochrome P450 (CYP2C18 based) [endoplasmic reticulum membrane] (Homo sapiens)
Activity
monooxygenase activity (GO:0004497)
Orthologous Events
CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Bos taurus)
CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Caenorhabditis elegans)
CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Danio rerio)
CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Dictyostelium discoideum)
CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Gallus gallus)
CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Mus musculus)
CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Rattus norvegicus)
CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Sus scrofa)
CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Xenopus tropicalis)
Authored
Jassal, B  (2008-05-19)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2008-02-08)
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