CYP2J2 oxidises ARA

Stable Identifier
R-HSA-211983
Type
Reaction
Species
Homo sapiens
Compartment
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Activation of phospholipases releases free arachidonic acid (ARA) from phospholipid bilayers which can then be metabolised to biologically active eicosanoids (signaling molecules which exert effects in inflammation and immunity). The cytochrome P450 enzyme CYP2J2 (arachidonic acid epoxygenase) is mainly expressed in human heart and can metabolise ARA to epoxyeicosatrienoic acid (EET). Four cis-EETs can be produced: 5,6-, 8,9-, 11,12- and 14,15-EET. Each of these can be formed as the R,S or the S,R enantiomer (Zeldin DC, 2001). The most abundant regioisomer in human heart is 14,15-EET although 11,12-EET possesses the most potent anti-inflammatory effect (Wu et al. 1996).

Literature References
PubMed ID Title Journal Year
8631948 Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart

Falck, JR, Wu, S, Zeldin, DC, Moomaw, CR, Tomer, KB

J Biol Chem 1996
8913342 CYP2J subfamily P450s in the lung: expression, localization, and potential functional significance

Steenbergen, C, Boyle, JE, Wu, S, Foley, J, Zeldin, DC, Ma, J, Moomaw, CR, Pascual, JM, Tomer, KB

Mol Pharmacol 1996
Participants
Participates
Catalyst Activity

arachidonic acid epoxygenase activity of Cytochrome P450 (CYP2J2 based) [endoplasmic reticulum membrane]

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