Reactome | CYP2J2 oxidises ARA

CYP2J2 oxidises ARA

Stable Identifier

R-HSA-211983

Type

Reaction [transition]

Species

Homo sapiens

Compartment

smooth endoplasmic reticulum

ReviewStatus

5/5

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Activation of phospholipases releases free arachidonic acid (ARA) from phospholipid bilayers which can then be metabolised to biologically active eicosanoids (signaling molecules which exert effects in inflammation and immunity). The cytochrome P450 enzyme CYP2J2 (arachidonic acid epoxygenase) is mainly expressed in human heart and can metabolise ARA to epoxyeicosatrienoic acid (EET). Four cis-EETs can be produced: 5,6-, 8,9-, 11,12- and 14,15-EET. Each of these can be formed as the R,S or the S,R enantiomer (Zeldin DC, 2001). The most abundant regioisomer in human heart is 14,15-EET although 11,12-EET possesses the most potent anti-inflammatory effect (Wu et al. 1996).

Literature References

PubMed ID	Title	Journal	Year
8631948	Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart Falck, JR, Wu, S, Zeldin, DC, Moomaw, CR, Tomer, KB	J Biol Chem	1996
8913342	CYP2J subfamily P450s in the lung: expression, localization, and potential functional significance Steenbergen, C, Boyle, JE, Wu, S, Foley, J, Zeldin, DC, Ma, J, Moomaw, CR, Pascual, JM, Tomer, KB	Mol Pharmacol	1996