The CYP3A family are the most abundantly expressed P450s in human liver, accounting for around 50% of xenobiotic drug metabolism. CYP3A4 is the most abundant member of the family and possesses broad specificity to a range of xenobiotics. Loperamide (LOP), an antidiarrheal, is mainly metabolized to desmethylloperamide (DLOP) through the N-demethylation pathway. This initial N-demethylation is carried out by CYP3A4.
Park, JY, Jung, DH, Kim, KA, Chung, J
monooxygenase activity of Cytochrome P450 (CYPIIIA4 based) [endoplasmic reticulum membrane]
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