Reactome | CYP3A4 can N-demethylate loperamide

CYP3A4 can N-demethylate loperamide

Stable Identifier

R-HSA-211948

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, endoplasmic reticulum lumen

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The CYP3A family are the most abundantly expressed P450s in human liver, accounting for around 50% of xenobiotic drug metabolism. CYP3A4 is the most abundant member of the family and possesses broad specificity to a range of xenobiotics. Loperamide (LOP), an antidiarrheal, is mainly metabolized to desmethylloperamide (DLOP) through the N-demethylation pathway. This initial N-demethylation is carried out by CYP3A4.

Literature References

PubMed ID	Title	Journal	Year
15365656	Identification of cytochrome P450 isoforms involved in the metabolism of loperamide in human liver microsomes Kim, KA, Chung, J, Jung, DH, Park, JY	Eur J Clin Pharmacol	2004