CYP4B1 12-hydroxylates ARA

Stable Identifier
R-HSA-211924
Type
Reaction
Species
Homo sapiens
Compartment
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Injury to the eye's surface provokes an inflammatory response, mediated, in part, by 12-hydroxyeicosanoids. CYP4B1 catalyses the 12-hydroxylation of arachidonic acid (ARA) to 12-HETE and 12-HETrE (12-hydroxy-5,8,10,14-eicosatetraenoic acid and 12-hydroxy-5,8,14-eicosatrienoic acid respectively). Both these metabolites possess potent inflammatory and angiogenic properties (Ashkar et al. 2004). The example of 12-HETE formation only is shown here.

Literature References
PubMed ID Title Journal Year
15006160 Retinoic acid induces corneal epithelial CYP4B1 gene expression and stimulates the synthesis of inflammatory 12-hydroxyeicosanoids

Mastyugin, V, Ashkar, S, Dunn, MW, Mesentsev, A, Zhang, WX, Laniado-Schwartzman, M

J Ocul Pharmacol Ther 2004
Participants
Participates
Catalyst Activity

monooxygenase activity of Cytochrome P450 (CYP4B1 based) [endoplasmic reticulum membrane]

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