Reactome | CYP4B1 12-hydroxylates ARA

CYP4B1 12-hydroxylates ARA

Stable Identifier

R-HSA-211924

Type

Reaction [transition]

Species

Homo sapiens

Compartment

smooth endoplasmic reticulum

ReviewStatus

5/5

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Injury to the eye's surface provokes an inflammatory response, mediated, in part, by 12-hydroxyeicosanoids. CYP4B1 catalyses the 12-hydroxylation of arachidonic acid (ARA) to 12-HETE and 12-HETrE (12-hydroxy-5,8,10,14-eicosatetraenoic acid and 12-hydroxy-5,8,14-eicosatrienoic acid respectively). Both these metabolites possess potent inflammatory and angiogenic properties (Ashkar et al. 2004). The example of 12-HETE formation only is shown here.

Literature References

PubMed ID	Title	Journal	Year
15006160	Retinoic acid induces corneal epithelial CYP4B1 gene expression and stimulates the synthesis of inflammatory 12-hydroxyeicosanoids Ashkar, S, Mesentsev, A, Zhang, WX, Mastyugin, V, Dunn, MW, Laniado-Schwartzman, M	J Ocul Pharmacol Ther	2004