CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation

Stable Identifier
R-HSA-211910
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, endoplasmic reticulum lumen
ReviewStatus
5/5
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CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation
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Paclitaxel (Taxol) is a naturally occurring member of the taxane family of antitumor drugs. It acts by stabilizing microtubules. Paclitaxel is inactivated in human liver by CYP2C8, which catalyzes 6alpha-hydroxylation of paclitaxel.
Literature References
PubMed ID Title Journal Year
9842986 Human liver microsomal metabolism of paclitaxel and drug interactions

Zhu, YW, Desai, PB, Duan, JZ, Kouzi, S

Eur J Drug Metab Pharmacokinet 1998
Participants
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Output
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as an event of
Catalyst Activity

monooxygenase activity of Cytochrome P450 (CYP2C8 based) [endoplasmic reticulum membrane]

Physical Entity
Cytochrome P450 (CYP2C8 based) [endoplasmic reticulum membrane] (Homo sapiens)
Activity
monooxygenase activity (GO:0004497)
Orthologous Events
CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Bos taurus)
CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Caenorhabditis elegans)
CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Dictyostelium discoideum)
CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Drosophila melanogaster)
CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Gallus gallus)
CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Mus musculus)
CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Rattus norvegicus)
CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Sus scrofa)
Authored
Jassal, B  (2008-05-19)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2008-02-08)
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