CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation

Stable Identifier
R-HSA-211910
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Paclitaxel (Taxol) is a naturally occurring member of the taxane family of antitumor drugs. It acts by stabilizing microtubules. Paclitaxel is inactivated in human liver by CYP2C8, which catalyzes 6alpha-hydroxylation of paclitaxel.

Literature References
PubMed ID Title Journal Year
9842986 Human liver microsomal metabolism of paclitaxel and drug interactions

Zhu, YW, Desai, PB, Duan, JZ, Kouzi, S

Eur J Drug Metab Pharmacokinet 1998
Participants
Participates
Catalyst Activity

monooxygenase activity of Cytochrome P450 (CYP2C8 based) [endoplasmic reticulum membrane]

Orthologous Events
Authored
Reviewed
Created
Cite Us!