Regulation of activated PAK-2p34 by proteasome mediated degradation

Stable Identifier
R-HSA-211733
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Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Regulation of activated PAK-2p34 by proteasome mediated degradation
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Stimulation of cell death by PAK-2 requires the generation and stabilization of the caspase-activated form, PAK-2p34 (Walter et al., 1998;Jakobi et al., 2003). Levels of proteolytically activated PAK-2p34 protein are controlled by ubiquitin-mediated proteolysis. PAK-2p34 but not full-length PAK-2 is degraded by the 26 S proteasome (Jakobi et al., 2003). It is not known whether ubiquitination and degradation of PAK-2p34 occurs in the cytoplasm or in the nucleus.
Literature References
PubMed ID Title Journal Year
9786869 Cleavage and activation of p21-activated protein kinase gamma-PAK by CPP32 (caspase 3). Effects of autophosphorylation on activity

Walter, BN, Huang, Z, Jakobi, R, Tuazon, PT, Alnemri, ES, Litwack, G, Traugh, JA

J Biol Chem 1998
12853446 Caspase-activated PAK-2 is regulated by subcellular targeting and proteasomal degradation

Jakobi, R, McCarthy, CC, Koeppel, MA, Stringer, DK

J Biol Chem 2003
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Go Biological Process
negative regulation of apoptotic process (0043066)
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BioModels Database
Authored
Jakobi, R  (2008-02-05)
Reviewed
Chang, E  (2008-05-21)
Created
Matthews, L  (2008-02-08)
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