Regulation of activated PAK-2p34 by proteasome mediated degradation

Stable Identifier
R-HSA-211733
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Regulation of activated PAK-2p34 by proteasome mediated degradation
Click the image above or here to open this pathway in the Pathway Browser
Stimulation of cell death by PAK-2 requires the generation and stabilization of the caspase-activated form, PAK-2p34 (Walter et al., 1998;Jakobi et al., 2003). Levels of proteolytically activated PAK-2p34 protein are controlled by ubiquitin-mediated proteolysis. PAK-2p34 but not full-length PAK-2 is degraded by the 26 S proteasome (Jakobi et al., 2003). It is not known whether ubiquitination and degradation of PAK-2p34 occurs in the cytoplasm or in the nucleus.
Literature References
PubMed ID Title Journal Year
9786869 Cleavage and activation of p21-activated protein kinase gamma-PAK by CPP32 (caspase 3). Effects of autophosphorylation on activity

Jakobi, R, Walter, BN, Huang, Z, Litwack, G, Traugh, JA, Tuazon, PT, Alnemri, ES

J Biol Chem 1998
12853446 Caspase-activated PAK-2 is regulated by subcellular targeting and proteasomal degradation

Koeppel, MA, Jakobi, R, McCarthy, CC, Stringer, DK

J Biol Chem 2003
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
negative regulation of apoptotic process (0043066)
Cross References
BioModels Database
Authored
Jakobi, R  (2008-02-05)
Reviewed
Chang, E  (2008-05-21)
Created
Matthews, L  (2008-02-08)
Cite Us!