Stimulation of cell death by PAK-2 requires the generation and stabilization of the caspase-activated form, PAK-2p34 (Walter et al., 1998;Jakobi et al., 2003). Levels of proteolytically activated PAK-2p34 protein are controlled by ubiquitin-mediated proteolysis. PAK-2p34 but not full-length PAK-2 is degraded by the 26 S proteasome (Jakobi et al., 2003). It is not known whether ubiquitination and degradation of PAK-2p34 occurs in the cytoplasm or in the nucleus.
Jakobi, R, Walter, BN, Huang, Z, Litwack, G, Traugh, JA, Tuazon, PT, Alnemri, ES
Koeppel, MA, Jakobi, R, McCarthy, CC, Stringer, DK
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