Ubiquitination of PAK-2p34

Stable Identifier
R-HSA-211734
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Ubiquitination of PAK-2p34
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PAK-2p34 is ubiquitinated prior to degradation (Jakobi et al., 2003). Here, ubiquitination of PAK-2p34 is described as occurring in the cytosol. However, to date it is not known whether this occurs in the nucleus or in the cytoplasm. Evidence for this reaction comes from experiments using both human and rabbit proteins. The polyubiquitin synthesized in the reaction is inferred to contain lysine-48 (K48) linkages because the modified protein is targeted to the proteasome (Komander 2009).
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Catalyst Activity

ubiquitin-protein transferase activity of Ubiquitin ligase [cytosol]

Physical Entity
Ubiquitin ligase [cytosol] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Inferred From
Ubiquitination of PAK-2p34 (Oryctolagus cuniculus)
Authored
Jakobi, R  (2008-02-05)
Reviewed
Chang, E  (2008-05-21)
Created
Matthews, L  (2008-02-08)
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