Reactome | AKT-mediated inactivation of FOXO1A

AKT-mediated inactivation of FOXO1A

Stable Identifier

R-HSA-211163

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this pathway in the Pathway Browser

The unphosphorylated form of FOXO1A shuttles between the nucleus and cytoplasm, maintaining a substantial concentration of this protein in the nucleoplasm, where it functions as a transcription factor. Phosphorylation of the protein, catalyzed by activated AKT, causes its exclusion from the nucleus (Zhang et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
12228231	Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding Unterman, TG, Gan, L, Pan, H, Zhang, X, Adam, S, Guo, S, Mesecar, A, Olson, ST, He, X	J Biol Chem	2002