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CYP2C19 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-211055
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Cytochrome P450 2C19, CPCJ_HUMAN
Locations in the PathwayBrowser
Expand all
Drug ADME (Homo sapiens)
Aspirin ADME (Homo sapiens)
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Homo sapiens)
CYP2,3 cytochromes [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C19 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Homo sapiens)
CYP2,3 cytochromes [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C19 [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
Cytochrome P450 - arranged by substrate type (Homo sapiens)
Xenobiotics (Homo sapiens)
CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Homo sapiens)
Cytochrome P450 (CYP2C18 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C19 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C19 5-hydroxylates omeprazole (Homo sapiens)
Cytochrome P450 (CYP2C19 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C19 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Homo sapiens)
Cytochrome P450 (CYP2C8 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C19 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Homo sapiens)
Cytochrome P450 (CYP2C9 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C19 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2D6 4-hydroxylates debrisoquine (Homo sapiens)
Cytochrome P450 (CYP2D6 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C19 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2E1 reactions (Homo sapiens)
Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C19 [endoplasmic reticulum membrane] (Homo sapiens)
Benzene is hydroxylated to phenol (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C19 [endoplasmic reticulum membrane] (Homo sapiens)
Dehalogenation of carbon tetrachloride to form a free radical (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C19 [endoplasmic reticulum membrane] (Homo sapiens)
Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C19 [endoplasmic reticulum membrane] (Homo sapiens)
MEOS oxidizes ethanol to acetaldehyde (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C19 [endoplasmic reticulum membrane] (Homo sapiens)
Vinyl chloride is oxidized to 2-Chloroethylene oxide (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C19 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2F1 dehydrogenates 3-methylindole (Homo sapiens)
Cytochrome P450 (CYP2F1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C19 [endoplasmic reticulum membrane] (Homo sapiens)
Coumarin is 7-hydroxylated by CYP2A13 (Homo sapiens)
Cytochrome P450 (CYP2A13 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C19 [endoplasmic reticulum membrane] (Homo sapiens)
Cyclophosphamide is 4-hydroxylated by CYP2B6 (Homo sapiens)
Cytochrome P450 (CYP2B6 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C19 [endoplasmic reticulum membrane] (Homo sapiens)
O-atom dealkylation of dextromethorphan (Homo sapiens)
Cytochrome P450 (CYP2D6 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C19 [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Arachidonate metabolism (Homo sapiens)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (Homo sapiens)
Arachidonate is hydroxylated to 19-HETE by CYP(2) (Homo sapiens)
CYP(2) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C19 [endoplasmic reticulum membrane] (Homo sapiens)
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Homo sapiens)
Arachidonate is epoxidated to 11,12-EET by CYP(5) (Homo sapiens)
CYP(5) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C19 [endoplasmic reticulum membrane] (Homo sapiens)
Arachidonate is epoxidated to 14,15-EET by CYP(5) (Homo sapiens)
CYP(5) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C19 [endoplasmic reticulum membrane] (Homo sapiens)
Arachidonate is epoxidated to 8,9-EET by CYP(5) (Homo sapiens)
CYP(5) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C19 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P33261 CYP2C19
Gene Names
CYP2C19
Chain
chain:1-490
Reference Genes
BioGPS Gene:1557 CYP2C19
COSMIC (genes):CYP2C19 CYP2C19
CTD Gene:1557 CYP2C19
dbSNP Gene:1557 CYP2C19
ENSEMBL:ENSG00000165841 CYP2C19
HGNC:2621 CYP2C19
KEGG:hsa:1557 CYP2C19
Monarch:1557 CYP2C19
NCBI Gene:1557 CYP2C19
OMIM:124020 CYP2C19
UCSC:P33261 CYP2C19
Reference Transcript
RefSeq:NM_000769.2 CYP2C19
Other Identifiers
1002_f_at
11715318_s_at
11759475_at
1557
16707744
216058_PM_s_at
216058_s_at
3258998
3258999
3259000
3259003
3259005
3259007
3259008
3259009
3259011
3259013
3259014
3259030
3259043
3259045
3259051
34078_s_at
7929478
A_14_P135829
A_23_P158481
A_23_P158484
A_33_P3326075
GO:0001676
GO:0003824
GO:0004497
GO:0005506
GO:0005737
GO:0005783
GO:0005789
GO:0005886
GO:0006629
GO:0006631
GO:0006805
GO:0008202
GO:0008392
GO:0008395
GO:0016020
GO:0016098
GO:0016491
GO:0016705
GO:0016712
GO:0018675
GO:0018676
GO:0019373
GO:0019825
GO:0019899
GO:0020037
GO:0042178
GO:0043226
GO:0043231
GO:0046872
GO:0052741
GO:0070330
GO:0097267
GO:0120319
HMNXSV003019042
Hs.296816.0.S1_3p_s_at
ILMN_1729191
PH_hs_0032475
TC10002971.hg
X65962_s_at
Participates
as a member of
CYP(5) [endoplasmic reticulum membrane] (Homo sapiens)
CYP(2) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2,3 cytochromes [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2C19 based) [endoplasmic reticulum membrane] (Homo sapiens)
as a candidate of
Cytochrome P450 (CYP2C9 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2B6 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2A13 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2D6 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2C18 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2F1 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2C8 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
Inferred To
Homologues of CYP2C19 [endoplasmic reticulum membrane]
(Bos taurus)
Homologues of CYP2C19 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
Homologues of CYP2C19 [endoplasmic reticulum membrane]
(Dictyostelium discoideum)
Homologues of CYP2C19 [endoplasmic reticulum membrane]
(Drosophila melanogaster)
Homologues of CYP2C19 [endoplasmic reticulum membrane]
(Mus musculus)
Homologues of CYP2C19 [endoplasmic reticulum membrane]
(Sus scrofa)
cyp-33e3 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
cyp-33c12 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
daf-9 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
CYP2C19 [endoplasmic reticulum membrane]
(Bos taurus)
CYP2C19 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
CYP2C19 [endoplasmic reticulum membrane]
(Dictyostelium discoideum)
CYP2C19 [endoplasmic reticulum membrane]
(Drosophila melanogaster)
CYP2C19 [endoplasmic reticulum membrane]
(Gallus gallus)
CYP2C19 [endoplasmic reticulum membrane]
(Mus musculus)
CYP2C19 [endoplasmic reticulum membrane]
(Rattus norvegicus)
CYP2C19 [endoplasmic reticulum membrane]
(Sus scrofa)
Cross References
ZINC - World Drugs
CP2CJ_HUMAN
Guide to Pharmacology - Targets
1328
ENSEMBL
ENST00000371321
,
ENSP00000360372
OpenTargets
ENSG00000165841
ZINC - FDA approved
CP2CJ_HUMAN
ZINC - Substances
CP2CJ_HUMAN
ZINC - Biogenic
CP2CJ_HUMAN
ZINC target
P33261
PRO
P33261
PDB
4GQS
ZINC - Investigational
CP2CJ_HUMAN
ZINC - Metabolites
CP2CJ_HUMAN
IntEnz
1.14.14.75
,
1.14.14.53
,
1.14.14.51
HPA
ENSG00000165841-CYP2C19
Pharos - Targets
P33261
ZINC - Predictions - Purchasable
CP2CJ_HUMAN
HMDB Protein
HMDBP01038
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