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CYP2C18 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-211035
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Cytochrome P450 2C18, CPCI_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
Cytochrome P450 - arranged by substrate type (Homo sapiens)
Xenobiotics (Homo sapiens)
CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Homo sapiens)
Cytochrome P450 (CYP2C18 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C18 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C19 5-hydroxylates omeprazole (Homo sapiens)
Cytochrome P450 (CYP2C19 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C18 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Homo sapiens)
Cytochrome P450 (CYP2C8 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C18 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Homo sapiens)
Cytochrome P450 (CYP2C9 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C18 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P33260 CYP2C18
Gene Names
CYP2C18
Chain
signal peptide:1-25, chain:26-490
Reference Genes
BioGPS Gene:1562 CYP2C18
COSMIC (genes):CYP2C18 CYP2C18
CTD Gene:1562 CYP2C18
dbSNP Gene:1562 CYP2C18
ENSEMBL:ENSG00000108242 CYP2C18
HGNC:2620 CYP2C18
Monarch:1562 CYP2C18
NCBI Gene:1562 CYP2C18
OMIM:601131 CYP2C18
UCSC:P33260 CYP2C18
Reference Transcript
RefSeq:NM_001128925.1 CYP2C18
RefSeq:NM_000772.2 CYP2C18
Other Identifiers
11735076_a_at
11735077_a_at
11735078_s_at
1477_s_at
1562
16707729
208126_PM_s_at
208126_s_at
215103_PM_at
215103_at
3258969
3258970
3258972
3258973
3258974
3258975
3258976
3258979
3258980
3258981
3258983
3258984
3258986
3258989
3258994
3258995
3258996
3259054
7929466
A_14_P130455
A_23_P52480
GE58010
GO:0003824
GO:0004497
GO:0005506
GO:0005737
GO:0005783
GO:0005789
GO:0005886
GO:0006629
GO:0006805
GO:0008392
GO:0008401
GO:0016020
GO:0016491
GO:0016705
GO:0016712
GO:0019369
GO:0019373
GO:0019825
GO:0020037
GO:0042572
GO:0042573
GO:0043226
GO:0043231
GO:0043651
GO:0046872
GO:0070330
GO:0071614
HMNXSV003002186
Hs.702.0.S1_3p_at
ILMN_1683121
M61853_at
TC10002972.hg
g13699815_3p_s_at
Participates
as a member of
Cytochrome P450 (CYP2C18 based) [endoplasmic reticulum membrane] (Homo sapiens)
as a candidate of
Cytochrome P450 (CYP2C19 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2C9 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2C8 based) [endoplasmic reticulum membrane] (Homo sapiens)
Inferred To
Homologues of CYP2C19 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
Homologues of CYP2C19 [endoplasmic reticulum membrane]
(Dictyostelium discoideum)
Homologues of CYP2C19 [endoplasmic reticulum membrane]
(Drosophila melanogaster)
Homologues of CYP2C19 [endoplasmic reticulum membrane]
(Sus scrofa)
cyp-33e3 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
cyp-33c12 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
daf-9 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
CYP2C18 [endoplasmic reticulum membrane]
(Mus musculus)
CYP2C18 [endoplasmic reticulum membrane]
(Rattus norvegicus)
CYP2C19 [endoplasmic reticulum membrane]
(Bos taurus)
CYP2C19 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
CYP2C19 [endoplasmic reticulum membrane]
(Dictyostelium discoideum)
CYP2C19 [endoplasmic reticulum membrane]
(Drosophila melanogaster)
CYP2C19 [endoplasmic reticulum membrane]
(Gallus gallus)
CYP2C19 [endoplasmic reticulum membrane]
(Sus scrofa)
Cross References
Guide to Pharmacology - Targets
1327
ENSEMBL
ENST00000285979
,
ENSP00000285979
,
ENSP00000341293
,
ENST00000339022
OpenTargets
ENSG00000108242
IntEnz
1.14.14.1
HPA
ENSG00000108242-CYP2C18
ZINC - Substances
CP2CI_HUMAN
ZINC target
P33260
PRO
P33260
Pharos - Targets
P33260
ZINC - Predictions - Purchasable
CP2CI_HUMAN
HMDB Protein
HMDBP01549
PDB
2H6P
,
2CIK
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