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CYP2B6 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-211010
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Cytochrome P450 2B6, CPB6_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
CYP3A4, CYP2B6 bind ritonavir (Homo sapiens)
CYP3A4, CYP2B6 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2B6 [endoplasmic reticulum membrane] (Homo sapiens)
CYP3A4,CYP2B6:ritinovir [endoplasmic reticulum membrane] (Homo sapiens)
CYP3A4, CYP2B6 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2B6 [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 - arranged by substrate type (Homo sapiens)
Fatty acids (Homo sapiens)
CYP2J2 oxidises ARA (Homo sapiens)
Cytochrome P450 (CYP2J2 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2B6 [endoplasmic reticulum membrane] (Homo sapiens)
Xenobiotics (Homo sapiens)
CYP2C19 5-hydroxylates omeprazole (Homo sapiens)
Cytochrome P450 (CYP2C19 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2B6 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Homo sapiens)
Cytochrome P450 (CYP2C8 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2B6 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Homo sapiens)
Cytochrome P450 (CYP2C9 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2B6 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2E1 reactions (Homo sapiens)
Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2B6 [endoplasmic reticulum membrane] (Homo sapiens)
Benzene is hydroxylated to phenol (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2B6 [endoplasmic reticulum membrane] (Homo sapiens)
Dehalogenation of carbon tetrachloride to form a free radical (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2B6 [endoplasmic reticulum membrane] (Homo sapiens)
Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2B6 [endoplasmic reticulum membrane] (Homo sapiens)
MEOS oxidizes ethanol to acetaldehyde (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2B6 [endoplasmic reticulum membrane] (Homo sapiens)
Vinyl chloride is oxidized to 2-Chloroethylene oxide (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2B6 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2F1 dehydrogenates 3-methylindole (Homo sapiens)
Cytochrome P450 (CYP2F1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2B6 [endoplasmic reticulum membrane] (Homo sapiens)
Coumarin is 7-hydroxylated by CYP2A13 (Homo sapiens)
Cytochrome P450 (CYP2A13 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2B6 [endoplasmic reticulum membrane] (Homo sapiens)
Cyclophosphamide is 4-hydroxylated by CYP2B6 (Homo sapiens)
Cytochrome P450 (CYP2B6 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2B6 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20813 CYP2B6
Gene Names
CYP2B6
Chain
chain:1-491
Reference Genes
BioGPS Gene:1555 CYP2B6
COSMIC (genes):CYP2B6 CYP2B6
CTD Gene:1555 CYP2B6
dbSNP Gene:1555 CYP2B6
ENSEMBL:ENSG00000197408 CYP2B6
HGNC:2615 CYP2B6
KEGG:hsa:1555 CYP2B6
Monarch:1555 CYP2B6
NCBI Gene:1555 CYP2B6
OMIM:123930 CYP2B6
UCSC:P20813 CYP2B6
Reference Transcript
RefSeq:NM_000767.4 CYP2B6
RefSeq:XM_011526550.2 CYP2B6
Other Identifiers
11729453_s_at
11729454_x_at
11729455_x_at
11751293_x_at
1371_s_at
1555
16862385
206754_PM_s_at
206754_s_at
206755_PM_at
206755_at
217133_PM_x_at
217133_x_at
3833898
3833899
3833906
3833907
3833908
3833916
3833927
3833928
3833930
3833931
3833932
3833933
3833934
3833935
3833936
3833940
3833941
3833942
3833943
3833944
3833945
8028963
A_14_P121550
A_14_P127320
A_23_P208373
A_24_P339514
GE57909
GO:0003824
GO:0004497
GO:0005506
GO:0005737
GO:0005783
GO:0005789
GO:0006629
GO:0006805
GO:0008202
GO:0008390
GO:0008392
GO:0016020
GO:0016491
GO:0016705
GO:0016712
GO:0019373
GO:0020037
GO:0042178
GO:0042180
GO:0043226
GO:0043231
GO:0046872
GO:0062184
GO:0062187
GO:0062188
GO:0062189
GO:0101021
HMNXSV003015251
HMNXSV003016200
HMNXSV003050747
Hs.1360.1.S1_3p_x_at
ILMN_1657529
ILMN_2215965
M29874_s_at
PH_hs_0036841
TC19000571.hg
g13699814_3p_at
g13699814_3p_s_at
Participates
as a member of
Cytochrome P450 (CYP2B6 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP3A4, CYP2B6 [endoplasmic reticulum membrane] (Homo sapiens)
as a candidate of
Cytochrome P450 (CYP2C19 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2C9 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2A13 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2F1 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2C8 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2J2 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
Inferred To
cyp-33e3 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
cyp-33c12 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
daf-9 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
Homologues of CYP2B6 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
Homologues of CYP2B6 [endoplasmic reticulum membrane]
(Dictyostelium discoideum)
Homologues of CYP2B6 [endoplasmic reticulum membrane]
(Drosophila melanogaster)
Homologues of CYP2B6 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
CYP2B6 [endoplasmic reticulum membrane]
(Bos taurus)
CYP2B6 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
CYP2B6 [endoplasmic reticulum membrane]
(Canis familiaris)
CYP2B6 [endoplasmic reticulum membrane]
(Danio rerio)
CYP2B6 [endoplasmic reticulum membrane]
(Dictyostelium discoideum)
CYP2B6 [endoplasmic reticulum membrane]
(Drosophila melanogaster)
CYP2B6 [endoplasmic reticulum membrane]
(Gallus gallus)
CYP2B6 [endoplasmic reticulum membrane]
(Mus musculus)
CYP2B6 [endoplasmic reticulum membrane]
(Rattus norvegicus)
CYP2B6 [endoplasmic reticulum membrane]
(Sus scrofa)
CYP2B6 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
Cross References
ZINC - World Drugs
CP2B6_HUMAN
Guide to Pharmacology - Targets
1324
ENSEMBL
ENSP00000324648
,
ENST00000324071
OpenTargets
ENSG00000197408
ZINC - FDA approved
CP2B6_HUMAN
ZINC - Substances
CP2B6_HUMAN
ZINC - Biogenic
CP2B6_HUMAN
ZINC target
P20813
PRO
P20813
PDB
4RRT
,
5UFG
,
5UEC
,
5UDA
,
4RQL
,
3QOA
,
3UA5
,
4I91
,
3IBD
,
5UAP
,
5WBG
,
3QU8
,
4ZV8
ZINC - Investigational
CP2B6_HUMAN
ZINC - Metabolites
CP2B6_HUMAN
HPA
ENSG00000197408-CYP2B6
Pharos - Targets
P20813
ZINC - Predictions - Purchasable
CP2B6_HUMAN
HMDB Protein
HMDBP01553
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