L-Glutamate loading of synaptic vesicle

Stable Identifier
R-HSA-210444
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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L-Glutamate loading of synaptic vesicle
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Nascent synaptic vesicles are loaded with glutamate by VGLUT1 to form glutamate containing synaptic vesicles. This process occurs while the synaptic vesicle is in the cytosol.
Literature References
PubMed ID Title Journal Year
18215623 Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3

Seal, RP, Akil, O, Yi, E, Weber, CM, Grant, L, Yoo, J, Clause, A, Kandler, K, Noebels, JL, Glowatzki, E, Lustig, LR, Edwards, RH

Neuron 2008
11001057 Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons

Takamori, S, Rhee, JS, Rosenmund, C, Jahn, R

Nature 2000
Participants
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Output
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Catalyst Activity

L-glutamate transmembrane transporter activity of Empty Glutamate Synaptic Vesicle [cytosol]

Physical Entity
Empty Glutamate Synaptic Vesicle [cytosol] (Homo sapiens)
Activity
L-glutamate transmembrane transporter activity (GO:0005313)
Orthologous Events
L-Glutamate loading of synaptic vesicle (Bos taurus)
L-Glutamate loading of synaptic vesicle (Caenorhabditis elegans)
L-Glutamate loading of synaptic vesicle (Canis familiaris)
L-Glutamate loading of synaptic vesicle (Danio rerio)
L-Glutamate loading of synaptic vesicle (Dictyostelium discoideum)
L-Glutamate loading of synaptic vesicle (Drosophila melanogaster)
L-Glutamate loading of synaptic vesicle (Mus musculus)
L-Glutamate loading of synaptic vesicle (Rattus norvegicus)
L-Glutamate loading of synaptic vesicle (Sus scrofa)
L-Glutamate loading of synaptic vesicle (Xenopus tropicalis)
Authored
Mahajan, SS  (2008-01-14)
Reviewed
Kavalali, E  (2008-04-24)
Created
Mahajan, SS  (2008-01-14)
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