Interaction of GPVI and FceRI gamma

Stable Identifier
R-HSA-210282
Type
Reaction [binding]
Species
Homo sapiens
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Glycoprotein VI (GPVI) was identified as a collagen receptor from studies of patients with a GPVI deficiency. GPVI-deficient platelets lack collagen-induced aggregation and the ability to form thrombi on a collagen surface under flow conditions. GPVI complexes with the Fc epsilon R1 receptor gamma chain, with a possible stochiometry of two GPVI molecules and one FceRI gamma-chain dimer (Jung & Moroi 2008). GPVI binding to FcR gamma is necessary for high affinity GPVI binding to collagen.

Literature References
PubMed ID Title Journal Year
16102042 GPVI and integrin alphaIIb beta3 signaling in platelets

Watson, SP, Auger, JM, McCarty, OJ, Pearce, AC

J Thromb Haemost 2005
9280292 Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma-chain

Gibbins, JM, Okuma, M, Farndale, R, Barnes, M, Watson, SP

FEBS Lett 1997
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