Reactome | Interaction of GPVI and FceRI gamma

Interaction of GPVI and FceRI gamma

Stable Identifier

R-HSA-210282

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Glycoprotein VI (GPVI) was identified as a collagen receptor from studies of patients with a GPVI deficiency. GPVI-deficient platelets lack collagen-induced aggregation and the ability to form thrombi on a collagen surface under flow conditions. GPVI complexes with the Fc epsilon R1 receptor gamma chain, with a possible stoichiometry of two GPVI molecules and one FceRI gamma-chain dimer (Jung & Moroi 2008). GPVI binding to FcR gamma is necessary for high affinity GPVI binding to collagen.

Literature References

PubMed ID	Title	Journal	Year
9280292	Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma-chain Gibbins, JM, Okuma, M, Farndale, R, Barnes, M, Watson, SP	FEBS Lett	1997
16102042	GPVI and integrin alphaIIb beta3 signaling in platelets Watson, SP, Auger, JM, McCarty, OJ, Pearce, AC	J Thromb Haemost	2005