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Go!
GC [extracellular region]
Stable Identifier
R-HSA-209886
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Vitamin D-binding protein (DBP), VTDB_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Vitamin D (calciferol) metabolism (Homo sapiens)
25(OH)D binds GC (Homo sapiens)
GC [extracellular region] (Homo sapiens)
GC:25(OH)D [extracellular region] (Homo sapiens)
GC [extracellular region] (Homo sapiens)
CUBN binds GC:25(OH)D (Homo sapiens)
CUBN:GC:25(OH)D [plasma membrane] (Homo sapiens)
GC:25(OH)D [extracellular region] (Homo sapiens)
GC [extracellular region] (Homo sapiens)
GC:25(OH)D [extracellular region] (Homo sapiens)
GC [extracellular region] (Homo sapiens)
LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D (Homo sapiens)
CUBN:GC:25(OH)D [plasma membrane] (Homo sapiens)
GC:25(OH)D [extracellular region] (Homo sapiens)
GC [extracellular region] (Homo sapiens)
VD3 binds GC (Homo sapiens)
GC [extracellular region] (Homo sapiens)
GC:VD3 [extracellular region] (Homo sapiens)
GC [extracellular region] (Homo sapiens)
VD3 dissociates from GC (Homo sapiens)
GC [extracellular region] (Homo sapiens)
GC:VD3 [extracellular region] (Homo sapiens)
GC [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P02774 GC
Gene Names
GC
Chain
signal peptide:1-16, chain:17-474
Reference Genes
BioGPS Gene:2638 GC
COSMIC (genes):GC GGCX
CTD Gene:2638 GC
dbSNP Gene:2638 GC
ENSEMBL:ENSG00000145321 GC
HGNC:4187 GC
KEGG:hsa:2638 GC
Monarch:2638 GC
NCBI Gene:2638 GC
OMIM:139200 GC
UCSC:P02774 GC
Reference Transcript
RefSeq:NM_001204307.1 GC
RefSeq:NM_001204306.1 GC
RefSeq:NM_000583.3 GC
Other Identifiers
11717587_a_at
16976676
204965_PM_at
204965_at
2638
2772808
2772810
2772811
2772813
2772816
2772817
2772818
2772819
2772822
2772823
2772824
2772825
2772826
2772827
2772828
2772829
2772835
2772836
2772837
2772839
32771_at
71811_r_at
8100853
A_23_P167349
GE80928
GO:0003779
GO:0005215
GO:0005499
GO:0005576
GO:0005615
GO:0005737
GO:0005829
GO:0006629
GO:0006766
GO:0008092
GO:0008289
GO:0035461
GO:0042359
GO:0043202
GO:0043226
GO:0051180
GO:0055085
GO:0070062
GO:0072562
GO:0090482
GO:1902118
HMNXSV003027416
ILMN_1736162
M11321_at
PH_hs_0025097
TC04001274.hg
g9845254_3p_at
Participates
as an input of
VD3 binds GC (Homo sapiens)
25(OH)D binds GC (Homo sapiens)
as an output of
VD3 dissociates from GC (Homo sapiens)
as a component of
GC:VD3 [extracellular region] (Homo sapiens)
GC:25(OH)D [extracellular region] (Homo sapiens)
Other forms of this molecule
GC [lysosomal lumen]
GC [cytosol]
Inferred To
GC [extracellular region]
(Bos taurus)
GC [extracellular region]
(Canis familiaris)
GC [extracellular region]
(Gallus gallus)
GC [extracellular region]
(Sus scrofa)
Gc [extracellular region]
(Mus musculus)
Gc [extracellular region]
(Rattus norvegicus)
gc [extracellular region]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001191236.1
,
NP_000574.2
,
NP_001191235.1
ZINC - World Drugs
VTDB_HUMAN
OpenTargets
ENSG00000145321
ENSEMBL
ENSG00000145321
,
ENST00000273951
,
ENST00000504199
,
ENSP00000273951
,
ENSP00000421725
ZINC - FDA approved
VTDB_HUMAN
ZINC - Substances
VTDB_HUMAN
ZINC - Biogenic
VTDB_HUMAN
ZINC target
P02774
PRO
P02774
GlyGen
P02774
PDB
1LOT
,
1J7E
,
1MA9
,
1KW2
,
1KXP
,
1J78
ZINC - Metabolites
VTDB_HUMAN
HPA
ENSG00000145321-GC
GeneCards
GC
Pharos - Targets
P02774
ZINC - Predictions - Purchasable
VTDB_HUMAN
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62736 ACTA2
1
ACTA2 [cytosol]
(R-HSA-445792)
0.527
3
UniProt:A5A3E0 POTEF
0.527
4
UniProt:Q9BYI3 HYCCI
0.527
2
UniProt:Q562R1 ACTBL
0.527
3
UniProt:P24468 NR2F2
1
NR2F2 [nucleoplasm]
(R-HSA-1183002)
0.527
2
UniProt:Q9BYX7 POTEKP
2
POTEKP [extracellular region]
(R-HSA-350725)
POTEKP [cytosol]
(R-HSA-350756)
0.527
2
UniProt:P0CG38 POTEI
0.527
4
UniProt:P60709 ACTB
5
ACTB [plasma membrane]
(R-HSA-196016)
ACTB [lysosomal membrane]
(R-HSA-196160)
ACTB [cytosol]
(R-HSA-201861)
ACTB [nucleoplasm]
(R-HSA-3321990)
Unfolded ACTB [cytosol]
(R-HSA-390462)
0.527
4
UniProt:Q9H8H2 DDX31
0.527
2
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