Reactome | Tryptophan is hydroxylated

Tryptophan is hydroxylated

Stable Identifier

R-HSA-209828

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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The first and rate limiting step in serotonin (5-HT) biosynthesis is catalyzed by tryptophan hydroxylase. The enzyme requires iron(II), tetrahydrobiopterin, and dioxygen cofactors for the hydroxylation of L-tryptophan to 5-hydroxytryptophan. Tryptophan hydroxylase belongs to a small family of monooxygenases that utilize tetrahydrobiopterins. Other members are phenylalanine hydroxylase and tyrosine hydroxylase (Fitzpatrick, PF, 1999; Walther et al, 2003).

Literature References

PubMed ID	Title	Journal	Year
12379098	Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin Wang, L, Erlandsen, H, Haavik, J, Knappskog, PM, Stevens, RC	Biochemistry	2002
12511643	Synthesis of serotonin by a second tryptophan hydroxylase isoform Walther, DJ, Peter, JU, Bashammakh, S, Hörtnagl, H, Voits, M, Fink, H, Bader, M	Science	2003