Reactome | Tryptophan is hydroxylated

Tryptophan is hydroxylated

Stable Identifier

R-HSA-209828

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The first and rate limiting step in serotonin (5-HT) biosynthesis is catalyzed by tryptophan hydroxylase. The enzyme requires iron(II), tetrahydrobiopterin, and dioxygen cofactors for the hydroxylation of L-tryptophan to 5-hydroxytryptophan. Tryptophan hydroxylase belongs to a small family of monooxygenases that utilize tetrahydrobiopterins. Other members are phenylalanine hydroxylase and tyrosine hydroxylase (Fitzpatrick, PF, 1999; Walther et al, 2003).

Literature References

PubMed ID	Title	Journal	Year
12379098	Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin Haavik, J, Erlandsen, H, Knappskog, PM, Wang, L, Stevens, RC	Biochemistry	2002
12511643	Synthesis of serotonin by a second tryptophan hydroxylase isoform Hörtnagl, H, Walther, DJ, Fink, H, Bashammakh, S, Voits, M, Bader, M, Peter, JU	Science	2003