Tryptophan is hydroxylated

Stable Identifier
R-HSA-209828
Type
Reaction
Species
Homo sapiens
Compartment
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The first and rate limiting step in serotonin (5-HT) biosynthesis is catalyzed by tryptophan hydroxylase. The enzyme requires iron(II), tetrahydrobiopterin, and dioxygen cofactors for the hydroxylation of L-tryptophan to 5-hydroxytryptophan. Tryptophan hydroxylase belongs to a small family of monooxygenases that utilize tetrahydrobiopterins. Other members are phenylalanine hydroxylase and tyrosine hydroxylase (Fitzpatrick, PF, 1999; Walther et al, 2003).

Literature References
PubMed ID Title Journal Year
12379098 Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin

Haavik, J, Erlandsen, H, Knappskog, PM, Wang, L, Stevens, RC

Biochemistry 2002
12511643 Synthesis of serotonin by a second tryptophan hydroxylase isoform

Hörtnagl, H, Walther, DJ, Fink, H, Bashammakh, S, Voits, M, Bader, M, Peter, JU

Science 2003
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Catalyst Activity

tryptophan 5-monooxygenase activity of TPH:Fe++ [cytosol]

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