NPHP4 protein binds LATS proteins

Stable Identifier
R-HSA-2059926
Type
Reaction
Species
Homo sapiens
Compartment
cytosol
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NPHP4 protein binds LATS proteins
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Cytosolic NPHP4 protein binds LATS proteins to form a complex. The stoiciometry of the resulting complex is unknown. When bound to NPHP4, LATS is unable to phosphorylate YAP1 and WWTR1 (TAZ) proteins, so the effect of NPHP4 binding is to antagonize this aspect of the Hippo cascade (Habbig et al. 2011).

Literature References
PubMed ID Title Journal Year
21555462 NPHP4, a cilia-associated protein, negatively regulates the Hippo pathway

Schermer, B, Bartram, MP, Sägmüller, JG, Hoehne, M, Habbig, S, Burst, V, Liebau, MC, Benzing, T, Reinhardt, HC, Müller, RU, Schwarz, R, Chen, S, Andriopoulos, N

J Cell Biol 2011
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Orthologous Events
NPHP4 protein binds LATS proteins (Caenorhabditis elegans)
NPHP4 protein binds LATS proteins (Canis familiaris)
NPHP4 protein binds LATS proteins (Danio rerio)
NPHP4 protein binds LATS proteins (Gallus gallus)
NPHP4 protein binds LATS proteins (Mus musculus)
NPHP4 protein binds LATS proteins (Rattus norvegicus)
NPHP4 protein binds LATS proteins (Sus scrofa)
Authored
D'Eustachio, P  (2012-02-03)
Reviewed
Sudol, M  (2012-02-03)
Created
D'Eustachio, P  (2012-01-14)
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