Reactome | NPHP4 [cytosol]

NPHP4 [cytosol]

Stable Identifier

R-HSA-2059925

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Nephrocystin-4

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O75161 NPHP4

Gene Names

NPHP4, KIAA0673

Chain

chain:1-1426

Reference Genes

BioGPS Gene:261734 NPHP4

COSMIC (genes):NPHP4 NPHP4

CTD Gene:261734 NPHP4

dbSNP Gene:261734 NPHP4

ENSEMBL:ENSG00000131697 NPHP4

ENSEMBL_homo_sapiens_GENE:ENSG00000131697.18 NPHP4

HGNC:19104 NPHP4

KEGG Gene (Homo sapiens):261734 NPHP4

Monarch:261734 NPHP4

NCBI Gene:261734 NPHP4

OMIM:607215 NPHP4

UCSC:O75161 NPHP4

Reference Transcript

Other Identifiers

11754699_a_at

16680962

16680964

213471_PM_at

213471_at

2394362

2394363

2394365

2394367

2394369

2394371

2394372

2394373

2394377

2394379

2394380

2394382

2394383

2394384

2394386

2394387

2394389

2394390

2394391

2394392

2394393

2394401

2394403

2394406

2394407

2394408

2394409

2394413

2394419

2394420

2394421

2394425

2394426

2394428

2394431

2394433

2394434

2394435

2394439

2394443

2394444

2394445

2394450

261734

37153_at

7911902

A_23_P351734

A_33_P3372389

GO:0005198

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005814

GO:0005815

GO:0005829

GO:0005856

GO:0005911

GO:0005923

GO:0005929

GO:0007010

GO:0007018

GO:0007155

GO:0007165

GO:0007632

GO:0016604

GO:0022414

GO:0023052

GO:0030036

GO:0030154

GO:0030317

GO:0032391

GO:0034330

GO:0035845

GO:0035869

GO:0036064

GO:0042995

GO:0043226

GO:0043231

GO:0045494

GO:0048856

GO:0048870

GO:0060041

GO:0070161

GO:0090090

GO:0097470

GO:0097546

GO:0097730

GO:0098609

GO:0120206

GO:1903348

GO:1904491

HMNXSV003021864

HMNXSV003027380

HMNXSV003031641

HMNXSV003036945

Hs.106487.0.S1_3p_at

ILMN_1808417

ILMN_2219512

PH_hs_0025359

TC01002142.hg

TC01002143.hg

Participates

as a component of

as an input of

NPHP4 protein binds LATS proteins (Homo sapiens)

Inferred To

NPHP4 [cytosol] (Bos taurus)

NPHP4 [cytosol] (Canis familiaris)

NPHP4 [cytosol] (Gallus gallus)

NPHP4 [cytosol] (Sus scrofa)

Nphp4 [cytosol] (Mus musculus)

Nphp4 [cytosol] (Rattus norvegicus)

nphp-4 [cytosol] (Caenorhabditis elegans)

Ghost homologue of NPHP4 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_055917.1, XP_011539518.1, NP_001278523.1, XP_011539519.1, XP_006710626.1, XP_016856486.1, NP_001278522.1, XP_011539520.1

OpenTargets

ENSG00000131697

GeneCards

O75161

HPA

ENSG00000131697-NPHP4

Ensembl

ENST00000378156, ENSP00000481831, ENST00000489180, ENSP00000367398, ENST00000622020, ENSP00000423747, ENSG00000131697

PRO

O75161

Pharos - Targets

O75161

Orphanet

16565

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15259 NPHP1	1	NPHP1 [cytosol] (R-HSA-5626654)	0.899	20
UniProt:Q92834 RPGR			0.73	5
UniProt:Q68CZ1-2 RPGRIP1L			0.696	8
UniProt:Q96KN7 RPGR1			0.618	3
UniProt:Q99615 DNAJC7	2	DNAJC7 [cytosol] (R-HSA-5252099) DNAJC7 [nucleoplasm] (R-HSA-5255408)	0.615	3
UniProt:Q68CZ1 RPGRIP1L	1	RPGRIP1L [cytosol] (R-HSA-5610418)	0.573	4
UniProt:O60232 ZNRD2			0.527	3
UniProt:Q9H4B7 TUBB1	6	TUBB1 folding intermediate [cytosol] (R-HSA-392793) TUBB1 unfolded [cytosol] (R-HSA-392782) Polyglycyl-TUBB1 [cytosol] (R-HSA-8867450) Polyglutamyl-TUBB1 [cytosol] (R-HSA-8867413) TUBB1 [axonemal microtubule] (R-HSA-5610437) TUBB1 [cytosol] (R-HSA-191703)	0.508	3
UniProt:O95816 BAG2	1	BAG2 [cytosol] (R-HSA-5255445)	0.483	2
UniProt:Q6IE81 JADE1	1	PHF17 [nucleoplasm] (R-HSA-452931)	0.463	4