SHP2 interacts with p-KIT

Stable Identifier
R-HSA-205238
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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SHP2 interacts with p-KIT
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SHP2 is a protein tyrosine phosphatase (PTP) with two NH2-terminal SH2 domains, a PTP domain, a -COOH tail with two tyrosyl phosphorylation sites at Y546 and Y584, and an interposed proline-rich domain. SHP2 binds to activated KIT on tyrosine-568 in the juxtamembrane region, which also constitutes the docking site for a number of other signal transduction molecules, such as SFKs, Csk homologous kinase (CHK), CBL, LNK and Adapter protein with PH and SH2 domains (APS) (Kozlowski et al. 1998, Price et al. 1997, Gueller et al. 2008).
Literature References
PubMed ID Title Journal Year
7523381 The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells

Pawson, T, Shen, R, Mantel, C, Feng, GS, Broxmeyer, HE, Marshall, MS, Tauchi, T

J Biol Chem 1994
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Orthologous Events
SHP2 interacts with p-KIT (Bos taurus)
SHP2 interacts with p-KIT (Canis familiaris)
SHP2 interacts with p-KIT (Gallus gallus)
SHP2 interacts with p-KIT (Mus musculus)
SHP2 interacts with p-KIT (Rattus norvegicus)
SHP2 interacts with p-KIT (Sus scrofa)
SHP2 interacts with p-KIT (Xenopus tropicalis)
Authored
Garapati, P V  (2011-07-11)
Reviewed
Rönnstrand, L  (2011-08-22)
Created
Garapati, P V  (2007-12-10)
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