PRDM4 inhibits cyclin E transcription

Stable Identifier
R-HSA-205056
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Within the nucleus, PRDM4 is found in a complex with HDACs (histone deacetylases) 1, 2, and 3. It interacts with the regulatory regions of the cyclin E gene, strongly inhibiting transcription. It was also shown to weakly affect cyclib B transcription. PRDM4 is believed to interact with regulatory regions of other genes, which are unknown.

Participants
Participant Of
Inferred From
Authored
Reviewed
Created