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p75NTR negatively regulates cell cycle via SC1
Stable Identifier
R-HSA-193670
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
p75NTR negatively regulates cell cycle via SC1 (Homo sapiens)
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SC1 (Schwann Cell factor 1; also called PR domain zinc finger protein 4, PRDM4) interacts with an NGF:p75NTR complex and signals cell cycle arrest by regulating the levels of cyclin E.
Literature References
PubMed ID
Title
Journal
Year
12371150
Control of the cell cycle by neurotrophins: lessons from the p75 neurotrophin receptor
Frade, JM
,
Lopez-Sanchez, N
Histol Histopathol
2002
Participants
Events
PRDM4 (SC1) binds to p75NTR
(Homo sapiens)
PRDM4 translocates to the nucleus
(Homo sapiens)
PRDM4 inhibits cyclin E transcription
(Homo sapiens)
Participates
as an event of
p75 NTR receptor-mediated signalling (Homo sapiens)
Event Information
Go Biological Process
negative regulation of cell cycle (0045786)
Authored
Nasi, S (2006-10-10)
Annibali, D (2006-10-10)
Reviewed
Friedman, WJ (2008-05-20)
Chao, MV (2008-05-28)
Created
Jassal, B (2007-02-23)
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