14-3-3epsilon attentuates NADE-related apoptosis

Stable Identifier
R-HSA-204981
Type
Reaction [binding]
Species
Homo sapiens
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NADE forms a complex with the 14-3-3epsilon isoform. The last one interacts with caspase 3 through its C terminal region. The NADE:4-3-3epsilon complex negatively regulates p75NTR-mediated apoptosis, probably by down regulating caspase activity.

Literature References
PubMed ID Title Journal Year
11278287 14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction

Kimura, MT, Irie, S, Shoji-Hoshino, S, Mukai, J, Nadano, D, Oshimura, M, Sato, TA

J Biol Chem 2001
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Orthologous Events
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