14-3-3epsilon attentuates NADE-related apoptosis

Stable Identifier
R-HSA-204981
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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14-3-3epsilon attentuates NADE-related apoptosis
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NADE forms a complex with the 14-3-3epsilon isoform. The last one interacts with caspase 3 through its C terminal region. The NADE:4-3-3epsilon complex negatively regulates p75NTR-mediated apoptosis, probably by down regulating caspase activity.
Literature References
PubMed ID Title Journal Year
11278287 14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction

Irie, S, Sato, TA, Mukai, J, Shoji-Hoshino, S, Oshimura, M, Nadano, D, Kimura, MT

J Biol Chem 2001
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Event Information
Go Biological Process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process (0043154)
Orthologous Events
14-3-3epsilon attentuates NADE-related apoptosis (Bos taurus)
14-3-3epsilon attentuates NADE-related apoptosis (Canis familiaris)
14-3-3epsilon attentuates NADE-related apoptosis (Mus musculus)
14-3-3epsilon attentuates NADE-related apoptosis (Rattus norvegicus)
14-3-3epsilon attentuates NADE-related apoptosis (Sus scrofa)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Friedman, WJ  (2008-05-20)
Chao, MV  (2008-05-28)
Created
Jassal, B  (2007-12-06)
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