NADE modulates death signalling

Stable Identifier
R-HSA-205025
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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NADE modulates death signalling
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NADE protein (p75NTR-associated cell death executor) may induce cell death upon NGF binding, but not BDNF, NT3, or NT4/5 binding, to p75NTR. The NADE-dependent apoptosis is modulated by the 14-3-3-epsilon protein (Kimura MT et al, 2001).
Literature References
PubMed ID Title Journal Year
11278287 14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction

Irie, S, Sato, TA, Mukai, J, Shoji-Hoshino, S, Oshimura, M, Nadano, D, Kimura, MT

J Biol Chem 2001
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Event Information
Go Biological Process
regulation of cysteine-type endopeptidase activity involved in apoptotic process (0043281)
Orthologous Events
NADE modulates death signalling (Bos taurus)
NADE modulates death signalling (Canis familiaris)
NADE modulates death signalling (Mus musculus)
NADE modulates death signalling (Rattus norvegicus)
NADE modulates death signalling (Sus scrofa)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Friedman, WJ  (2008-05-20)
Chao, MV  (2008-05-28)
Created
Jassal, B  (2007-12-06)
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