Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA

Stable Identifier
R-HSA-2046092
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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DGL-CoA (8,11,14-eicosatrienoyl-CoA) undergoes desaturation by delta 5-desaturase (D5-desaturase) forming arachidonoyl-CoA (AA-CoA, 5,8,11,14-Eicosatetraenoic acid). D5-desaturase has 62% sequence identity with D6-desaturase but desaturates a different carbon atom, adding a double bond at position C5 in arachidonoyl-CoA (AA-CoA). AA can be metabolized by variety of oxygenases (including cyclo-oxygenase and lipoxygenase systems) to form a family of varying products known as eicosanoids, prostaglandins, leukotrines and thromboxanes thus playing important role in inflamation response.

Literature References
PubMed ID Title Journal Year
10601301 Cloning, expression, and fatty acid regulation of the human delta-5 desaturase

Cho, HP, Nakamura, M, Clarke, SD

J Biol Chem 1999
10769175 cDNA cloning and characterization of human Delta5-desaturase involved in the biosynthesis of arachidonic acid

Leonard, AE, Kelder, B, Bobik, EG, Chuang, LT, Parker-Barnes, JM, Thurmond, JM, Kroeger, PE, Kopchick, JJ, Huang, YS, Mukerji, P

Biochem J 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
omega-6 fatty acid desaturase activity of FADS1 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
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