Reactome | Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA

Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA

Stable Identifier

R-HSA-2046092

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen, endoplasmic reticulum membrane

ReviewStatus

5/5

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Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA

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DGL-CoA (8,11,14-eicosatrienoyl-CoA) undergoes desaturation by delta 5-desaturase (D5-desaturase) forming arachidonoyl-CoA (AA-CoA, 5,8,11,14-Eicosatetraenoic acid). D5-desaturase has 62% sequence identity with D6-desaturase but desaturates a different carbon atom, adding a double bond at position C5 in arachidonoyl-CoA (AA-CoA). AA can be metabolized by variety of oxygenases (including cyclo-oxygenase and lipoxygenase systems) to form a family of varying products known as eicosanoids, prostaglandins, leukotrines and thromboxanes thus playing important role in inflamation response.

Literature References

PubMed ID	Title	Journal	Year
10769175	cDNA cloning and characterization of human Delta5-desaturase involved in the biosynthesis of arachidonic acid Leonard, AE, Kelder, B, Bobik, EG, Chuang, LT, Parker-Barnes, JM, Thurmond, JM, Kroeger, PE, Kopchick, JJ, Huang, YS, Mukerji, P	Biochem J	2000
10601301	Cloning, expression, and fatty acid regulation of the human delta-5 desaturase Cho, HP, Nakamura, M, Clarke, SD	J Biol Chem	1999