Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA

Stable Identifier
R-HSA-2046090
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen, endoplasmic reticulum membrane
ReviewStatus
5/5
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Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Docosapentaenoyl-CoA is elongated to tetracosapentaenoyl-CoA (9,12,15,18,21-24:5(n-3)) by the enzyme ELOVL2.
Literature References
PubMed ID Title Journal Year
1834642 The metabolism of 7,10,13,16,19-docosapentaenoic acid to 4,7,10,13,16,19-docosahexaenoic acid in rat liver is independent of a 4-desaturase

Voss, A, Reinhart, M, Sankarappa, S, Sprecher, H

J Biol Chem 1991
14636670 Elongation of long-chain fatty acids

Leonard, AE, Pereira, SL, Sprecher, H, Huang, YS

Prog Lipid Res 2004
Participants
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Output
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as an event of
Catalyst Activity

fatty acid elongase activity of ELOVL2 [endoplasmic reticulum membrane]

Physical Entity
ELOVL2 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
fatty acid elongase activity (GO:0009922)
Orthologous Events
Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Bos taurus)
Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Canis familiaris)
Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Danio rerio)
Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Dictyostelium discoideum)
Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Drosophila melanogaster)
Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Gallus gallus)
Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Mus musculus)
Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Plasmodium falciparum)
Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Rattus norvegicus)
Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Sus scrofa)
Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Xenopus tropicalis)
Authored
Garapati, P V  (2012-01-11)
Created
Garapati, P V  (2012-01-11)
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