SDA-CoA (6,9,12,15-18:4(n-3)) is rapidly elongated by two carbon atoms to 8,11,14,17-eicosatetraenoyl-CoA (8,11,14,17-20:4(n-3), ETA-CoA). The NADPH-consuming enzyme long-chain fatty acyl elongase (ELOVL5) mediates this reaction which and adds malonyl-CoA to the SDA-CoA and releases carbon dioxide and free CoA (Leonard et al. 2004).
Huang, YS, Chaung, LT, Parker-Barnes, JM, Bobik, E, Das, T, Mukerji, P, Leonard, AE, Thurmond, JM
Cleland, LG, James, MJ, Ursin, VM
fatty acid elongase activity of ELOVL1,2,3,5 [endoplasmic reticulum membrane]
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