Reactome | Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA

Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA

Stable Identifier

R-HSA-2046088

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen, endoplasmic reticulum membrane

ReviewStatus

5/5

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Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA

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SDA-CoA (6,9,12,15-18:4(n-3)) is rapidly elongated by two carbon atoms to 8,11,14,17-eicosatetraenoyl-CoA (8,11,14,17-20:4(n-3), ETA-CoA). The NADPH-consuming enzyme long-chain fatty acyl elongase (ELOVL5) mediates this reaction which and adds malonyl-CoA to the SDA-CoA and releases carbon dioxide and free CoA (Leonard et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
10899997	Identification and characterization of an enzyme involved in the elongation of n-6 and n-3 polyunsaturated fatty acids Huang, YS, Chaung, LT, Parker-Barnes, JM, Bobik, E, Das, T, Mukerji, P, Leonard, AE, Thurmond, JM	Proc Natl Acad Sci U S A	2000
12716664	Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n-3 fatty acids Cleland, LG, James, MJ, Ursin, VM	Am J Clin Nutr	2003