Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA

Stable Identifier
R-HSA-2046088
Type
Reaction
Species
Homo sapiens
Compartment
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SDA-CoA (6,9,12,15-18:4(n-3)) is rapidly elongated by two carbon atoms to 8,11,14,17-eicosatetraenoyl-CoA (8,11,14,17-20:4(n-3), ETA-CoA). The NADPH-consuming enzyme long-chain fatty acyl elongase (ELOVL5) mediates this reaction which and adds malonyl-CoA to the SDA-CoA and releases carbon dioxide and free CoA (Leonard et al. 2004).

Literature References
PubMed ID Title Journal Year
10899997 Identification and characterization of an enzyme involved in the elongation of n-6 and n-3 polyunsaturated fatty acids

Huang, YS, Chaung, LT, Parker-Barnes, JM, Bobik, E, Das, T, Mukerji, P, Leonard, AE, Thurmond, JM

Proc Natl Acad Sci U S A 2000
12716664 Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n-3 fatty acids

Cleland, LG, James, MJ, Ursin, VM

Am J Clin Nutr 2003
Participants
Participates
Catalyst Activity

fatty acid elongase activity of ELOVL1,2,3,5 [endoplasmic reticulum membrane]

Orthologous Events
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