Reactome | Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA

Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA

Stable Identifier

R-HSA-2046088

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen, endoplasmic reticulum membrane

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Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA

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SDA-CoA (6,9,12,15-18:4(n-3)) is rapidly elongated by two carbon atoms to 8,11,14,17-eicosatetraenoyl-CoA (8,11,14,17-20:4(n-3), ETA-CoA). The NADPH-consuming enzyme long-chain fatty acyl elongase (ELOVL5) mediates this reaction which and adds malonyl-CoA to the SDA-CoA and releases carbon dioxide and free CoA (Leonard et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
12716664	Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n-3 fatty acids James, MJ, Ursin, VM, Cleland, LG	Am J Clin Nutr	2003
10899997	Identification and characterization of an enzyme involved in the elongation of n-6 and n-3 polyunsaturated fatty acids Parker-Barnes, JM, Das, T, Bobik, E, Leonard, AE, Thurmond, JM, Chaung, LT, Huang, YS, Mukerji, P	Proc Natl Acad Sci U S A	2000