Reactome | SCP2 [peroxisomal matrix]

SCP2 [peroxisomal matrix]

Stable Identifier

R-HSA-2046067

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

peroxisomal matrix

Synonyms

SCPx thiolase (SCPX), Non-specific lipid-transfer protein, NLTP_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P22307 SCP2

Gene Names

SCP2

Chain

chain:1-547

Reference Genes

BioGPS Gene:6342 SCP2

COSMIC (genes):SCP2 SCP2

CTD Gene:6342 SCP2

dbSNP Gene:6342 SCP2

ENSEMBL:ENSG00000116171 SCP2

HGNC:10606 SCP2

KEGG Gene (Homo sapiens):6342 SCP2

Monarch:6342 SCP2

NCBI Gene:6342 SCP2

OMIM:184755 SCP2

UCSC:P22307 SCP2

Reference Transcript

Other Identifiers

0001850605

11734259_a_at

11745850_a_at

11756580_x_at

11761075_a_at

16664802

1QND

201339_s_at

211733_x_at

2336586

2336587

2336590

2336592

2336593

2336594

2336595

2336596

2336598

2336599

2336600

2336601

2336602

2336603

2336604

2336606

2336607

2336608

2336609

2336610

2336612

2336613

2336617

2336618

2336619

2336620

2336621

2336622

2336623

2336624

2336629

27101

27135

27317

2C0L

36688_at

59385_at

6342

7901513

90029_at

A0A384NY87

A_14_P129129

A_23_P126057

A_24_P156922

AAA03557

AAA03558

AAA03559

AAB24921

AAB41286

AAH05911

AAH67108

AC099677

ADO22217

AK294631

AK295214

AK308105

AL445183

BAG57810

BAG58208

BC005911

BC067108

CB997588

CCDS30719

CCDS41338

CCDS44149

CCDS44150

CCDS53317

CCDS53318

CCDS53319

CCDS572

CH471059

CR995014

E9PLD1

EAX06760

EAX06761

ENSG00000116171

ENSP00000360564

ENSP00000360568

ENSP00000360569

ENSP00000384569

ENSP00000386214

ENSP00000396413

ENSP00000406636

ENSP00000434132

ENSP00000435783

ENST00000371509

ENST00000371509.8

ENST00000371513

ENST00000371513.9

ENST00000371514

ENST00000371514.7

ENST00000407246

ENST00000407246.6

ENST00000408941

ENST00000408941.7

ENST00000430330

ENST00000430330.6

ENST00000435345

ENST00000435345.6

ENST00000488965

ENST00000488965.1

ENST00000528311

ENST00000528311.5

EntrezGene:6342

EntrezGene:SCP2

g13543502_3p_at

g4506822_3p_s_at

GE58925

GE84308

GO:0000062

GO:0003674

GO:0003824

GO:0005102

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005777

GO:0005782

GO:0005829

GO:0006605

GO:0006625

GO:0006629

GO:0006694

GO:0006699

GO:0006810

GO:0006869

GO:0007031

GO:0008150

GO:0008289

GO:0009056

GO:0009058

GO:0015031

GO:0015485

GO:0015914

GO:0016020

GO:0016740

GO:0016746

GO:0016747

GO:0032385

GO:0032934

GO:0032991

GO:0033540

GO:0033814

GO:0036042

GO:0036109

GO:0043167

GO:0043226

GO:0043231

GO:0044281

GO:0050632

GO:0070538

GO:1901373

GQ891355

HGNC:10606

HPA027101

HPA027135

HPA027317

ILMN_1674955

ILMN_1694776

IPR003033

IPR016039

IPR020613

IPR020615

IPR020616

IPR020617

IPR036527

M55421

M75883

M75884

MIM:184755

MIM:613724

NM_001007098

NM_001007099

NM_001007100

NM_001007250

NM_001193599

NM_001193600

NM_001193617

NM_002979

NP_001007099

NP_001007100

NP_001007101

NP_001007251

NP_001180528

NP_001180529

NP_001180546

NP_002970

PF00108

PF02036

PF02803

PH_hs_0004367

S52450

SCP2

SCP2-201

SCP2-202

SCP2-203

SCP2-204

SCP2-205

SCP2-206

SCP2-207

SCP2-212

SCP2-213

TC01000648.hg

U11297

U11299

U11300

U11301

U11302

U11303

U11304

U11305

U11306

U11307

U11308

U11309

U11310

U11311

U11312

U11313

U11313_at

UPI0000000C71

UPI0000130258

UPI000034E592

UPI00004703AF

UPI00004703B0

UPI0000D61F1F

UPI00017A730D

UPI0001DD3808

XM_005271103

XP_005271160

Participant Of

input

TYSND1 cleaves SCP2

hasMember

Cargo proteins containing PTS1 [peroxisomal matrix]

Other forms of this molecule

SCP2(425-547) [peroxisomal matrix]

SCP2(1-424) [peroxisomal matrix]

SCP2 [cytosol]

Inferred To

SCP2-1 [peroxisomal matrix] (Danio rerio)

SCP2-1 [peroxisomal matrix] (Xenopus tropicalis)

Scp2 [peroxisomal matrix] (Rattus norvegicus)

ScpX [peroxisomal matrix] (Drosophila melanogaster)

SCP2D1 [peroxisomal matrix] (Sus scrofa)

Scp2d1 [peroxisomal matrix] (Mus musculus)

Scp2d1 [peroxisomal matrix] (Rattus norvegicus)

Homologues of SCP2-1 [peroxisomal matrix] (Mus musculus)

Homologues of SCP2-1 [peroxisomal matrix] (Rattus norvegicus)

SCP2 [peroxisomal matrix] (Bos taurus)

SCP2 [peroxisomal matrix] (Canis familiaris)

SCP2 [peroxisomal matrix] (Gallus gallus)

daf-22 [peroxisomal matrix] (Caenorhabditis elegans)

Scp2(1-547) [peroxisomal matrix] (Mus musculus)

Cross References

RefSeq

NP_001007100.1, NP_001007101.1, NP_002970.2, NP_001180528.1, XP_016857535.1, NP_001007099.1, NP_001007251.1, NP_001180546.1

OpenTargets

ENSG00000116171

ZINC - Substances

NLTP_HUMAN

ZINC target

P22307

PRO

P22307

PDB

1QND, 2C0L

IntEnz

2.3.1.176

HPA

ENSG00000116171-SCP2

GeneCards

P22307

Ensembl

ENSP00000386214, ENST00000528311, ENST00000371509, ENSP00000434132, ENST00000371514, ENSP00000384569, ENST00000435345, ENSP00000360569, ENSG00000116171, ENST00000408941, ENSP00000360564, ENSP00000396413, ENST00000430330, ENSP00000435783, ENST00000407246, ENSP00000406636, ENSP00000360568, ENST00000371513, ENST00000488965

Orphanet

17584

ZINC - Predictions - Purchasable

NLTP_HUMAN

HMDB Protein

HMDBP00440

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15645 PCH2			0.666	4
UniProt:Q03135 CAV1	5	CAV1 [early endosome membrane] (R-HSA-5368451) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [endocytic vesicle membrane] (R-HSA-535009) CAV1 [Golgi membrane] (R-HSA-204504)	0.482	3
UniProt:P49817 Cav1	6	Cav1 [Golgi membrane] (R-MMU-204504) caveolin-1 [lipid droplet] (R-MMU-163603) Cav1 [endocytic vesicle membrane] (R-MMU-535009) Cav1 [lipid droplet] (R-MMU-163510) Cav1 [early endosome membrane] (R-MMU-5368451) Cav1 [plasma membrane] (R-MMU-534994)	0.463	3

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